Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

doi:10.1016/S1875-5364(24)60601-1

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	Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora
	Xu, Shuangyu; Zhang, Feng; Tao, Linlan; Jiang, Yangming; Huang, Tao; Li, Yanan; Hu, Zhanxing; Yang, Jue; Hao, Xiaojiang; Yuan, Chunmao
	2024
发表期刊	CHINESE JOURNAL OF NATURAL MEDICINES
ISSN	2095-6975
卷号	22 期号:3 页码:265-272
摘要	Four new sesquiterpene lactones (SLs) ( 1 - 4 ), along with a biosynthetically related SL ( 5 ), have been isolated from the leaves of Magnolia grandiflora . Magrandate A ( 1 ) is notable as the first C18 homogemarane type SL, featuring a unique 1,7-dioxaspiro[4.4]nonan-6-one core. Compounds 2 and 3 , representing the first instances of chlorine -substituted gemarane-type SL analogs in natural products, were also identified. The structures of these isolates were elucidated through a combination of spectroscopic data analysis, electronic circular dichroism calculations, and X-ray single -crystal diffraction analysis. All isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 cells. Notably, 3 - 5 showed a significant inhibitory effect on nitric oxide production, with IC 50 values ranging from 0.79 to 4.73 mu molL -1 . Additionally, 4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines, with IC 50 values between 3.09 and 11.23 mu molL -1 .
DOI	10.1016/S1875-5364(24)60601-1
WOS记录号	WOS:001225639500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76314
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xu, Shuangyu,Zhang, Feng,Tao, Linlan,et al. Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(3):265-272.
APA	Xu, Shuangyu.,Zhang, Feng.,Tao, Linlan.,Jiang, Yangming.,Huang, Tao.,...&Yuan, Chunmao.(2024).Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora.CHINESE JOURNAL OF NATURAL MEDICINES,22(3),265-272.
MLA	Xu, Shuangyu,et al."Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora".CHINESE JOURNAL OF NATURAL MEDICINES 22.3(2024):265-272.

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