Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145

doi:10.1021/acs.jnatprod.3c00892

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	Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145
	Wang, Tingting; Feng, Yunping; Huang, Jian; Wu, Sitong; Hu, Kun; Wu, Jiabin; Naman, C. Benjamin; Wang, Hong; Lin, Wenhan; He, Shan
	2024
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	87 期号:1 页码:160-165
摘要	One novel rearranged pimarane diterpenoid, pestanoid A (1), and two reported molecules, nodulisporenones A (2) and B (3), were discovered from Pestalotiopsis sp. NBUF145 fungus associated with a 62 m deep mesophotic (twilight) zone Chalinidae sponge. The structures of 1-3 were identified by spectrometry, spectroscopy, quantum-chemical calculations, and X-ray crystallography. Compounds 1 and 2 inhibited bone marrow monocyte osteoclastogenesis in vitro with the IC50 values 4.2 +/- 0.2 mu M and 3.0 +/- 0.4 mu M, respectively, without observed cytotoxicity. Both 1 and 2 suppressed the receptor activator of NF-kB ligand-induced MAPK and NF-kappa B signaling by inhibiting the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-kappa B nuclear translocation.
DOI	10.1021/acs.jnatprod.3c00892
WOS记录号	WOS:001152648700001
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76242
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Tingting,Feng, Yunping,Huang, Jian,et al. Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(1):160-165.
APA	Wang, Tingting.,Feng, Yunping.,Huang, Jian.,Wu, Sitong.,Hu, Kun.,...&He, Shan.(2024).Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145.JOURNAL OF NATURAL PRODUCTS,87(1),160-165.
MLA	Wang, Tingting,et al."Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145".JOURNAL OF NATURAL PRODUCTS 87.1(2024):160-165.

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