Artemordosins A- L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica

doi:10.1016/j.phytochem.2024.114374

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	Artemordosins A- L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica
	Wang, Yuan; Li, Tian-Ze; Ma, Yun-Bao; Geng, Chang-An; Wang, Yong Cui; Chen, Ji-Jun
	2025
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	232 页码:114374
摘要	Two unprecedented sesquiterpene and monoterpene heterodimers and ten previously undescribed sesquiterpenoids, artemordosins A-L (1-12), as well as ten known sesquiterpenoids (13-22), were obtained from Artemisia ordosica. Their structures were elucidated based on comprehensive analyses of NMR, IR, HRESIMS, GIAO NMR calculations with DP4+ probability analysis, and ECD calculations. Notably, artemordosins A and B (1 and 2 ) were the first examples of cadinane-monoterpene dimers, and artemordosin A (1) was a cadinane-myrceane heterodimer with a 6/6/6/6 ring system formed by [4 + 2] cycloaddition, while artemordosin B (2) was a 4,5seco-cadinane-artemisane dimer connected through a C-5- O-C-4 ' linkage. Artemordosin C (3) was the first example of 10(5 -> 4)-abeo-eudesmane sesquiterpenoid featuring an unprecedented bicyclo[5.3.0]decane skeleton in natural products. Artemordosin B (2) and epi-deoxyarteannuin B ( 14) showed inhibitory activity on three hepatoma cells with IC50 values of 37.1 and 15.4 mu M (HepG2), 27.7 and 16.4 mu M (Huh-7), 39.6 and 22.6 mu M (SKHep-1).
DOI	10.1016/j.phytochem.2024.114374
WOS记录号	WOS:001394910500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76220
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Yuan,Li, Tian-Ze,Ma, Yun-Bao,et al. Artemordosins A- L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica[J]. PHYTOCHEMISTRY,2025,232:114374.
APA	Wang, Yuan,Li, Tian-Ze,Ma, Yun-Bao,Geng, Chang-An,Wang, Yong Cui,&Chen, Ji-Jun.(2025).Artemordosins A- L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica.PHYTOCHEMISTRY,232,114374.
MLA	Wang, Yuan,et al."Artemordosins A- L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica".PHYTOCHEMISTRY 232(2025):114374.

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