Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity

doi:10.1002/cbdv.202401720

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	Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity
	Wang, Yue-Hu
	2025
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	22 期号:1 页码:e202401720
摘要	Polyhydroxylated spirostanol saponins, characterized by three or more hydroxy substitutions in the aglycone, have various interesting biological activities. In the present study, steroids, saponins, polyhydroxylated, spirostanol saponins, and steroidal saponins were used as search terms to screen the literature. Cited references were collected between 1950 and 2023 from the Web of Science, SciFinder, and China National Knowledge Internet (CNKI). A total of 407 polyhydroxylated spirostanol saponins were included in this review. These saponins were classified into three types, alpha, beta, and gamma. Polyhydroxylated spirostanol saponins have potential benefits, primarily anti-inflammatory, antimicrobial, cytotoxic, and cAMP phosphodiesterase inhibitory activities. These compounds were found in 11 plant families and 36 genera. The top three families containing the most saponins were Asparagaceae, Melanthiaceae, and Amaryllidaceae, and the top five genera were Trillium, Helleborus, Allium, Dracaena, and Paris. The top five plants were Trillium tschonoskii Maxim., Ypsilandra thibetica Franch., Paris polyphylla var. yunnanensis (Franch.)Hand.-Mazz., Helleborus thibetanus Franch., and Helleborus foetidus L. On the basis of their diverse biological activities, these saponins and related plant resources are worthy of further development and utilization.
DOI	10.1002/cbdv.202401720
WOS记录号	WOS:001357416000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76197
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Yue-Hu. Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity[J]. CHEMISTRY & BIODIVERSITY,2025,22(1):e202401720.
APA	Wang, Yue-Hu.(2025).Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity.CHEMISTRY & BIODIVERSITY,22(1),e202401720.
MLA	Wang, Yue-Hu."Naturally Occurring Polyhydroxylated Spirostanol Saponins, A Review of the Classification, Sources, Biosynthesis, Biological Activities, and Toxicity".CHEMISTRY & BIODIVERSITY 22.1(2025):e202401720.

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10.1002_cbdv.2024017（1725KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载