Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content

doi:10.1016/j.funbio.2024.08.012

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	Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content
	Gao, Bo; Yu, Buzhu; Huang, Xing; Li, He; Jia, Yanxia; Wang, Mulan; Lu, Yuanxue; Zhang, Xudong; Li, Weiqi
	2024
发表期刊	FUNGAL BIOLOGY
ISSN	1878-6146
卷号	128 期号:7 页码:2190-2196
摘要	Heavy metal Cd2+ can easily be accumulated by fungi, causing significant stress, with the fungal cell membrane being one of the primary targets. However, the understanding of the mechanisms behind this stress remains limited. This study investigated the changes in membrane lipid molecules of Pleurotus ostreatus mycelia under Cd2+ stress and the antagonistic effect of Ca2+ on this stress. Cd2+ in the growth media significantly inhibited mycelial growth, with increasing intensity at higher concentrations. The addition of Ca2+ mitigated this Cd2+-induced growth inhibition. Lipidomic analysis showed that Cd2+ reduced membrane lipid content and altered lipid composition, while Ca2+ counteracted these changes. The effects of both Cd2+ and Ca2+ on lipids are dose dependent and phosphatidylethanolamine appeared most affected. Cd2+ also caused a phosphatidylcholine/phosphatidylethanolamine ratio increase at high concentrations, but Ca2+ helped maintain normal levels. The acyl chain length and unsaturation of lipids remained unaffected, suggesting Cd2+ doesn't alter acyl chain structure of lipids. These findings suggest that Cd2+ may affect the growth of mycelia by inhibiting the synthesis of membrane lipids, particular the synthesis of phosphatidylethanolamine, providing novel insights into the mechanisms of Cd2+ stress in fungi and the role of Ca2+ in mitigating the stress.
DOI	10.1016/j.funbio.2024.08.012
WOS记录号	WOS:001322637600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76180
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Gao, Bo,Yu, Buzhu,Huang, Xing,et al. Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content[J]. FUNGAL BIOLOGY,2024,128(7):2190-2196.
APA	Gao, Bo.,Yu, Buzhu.,Huang, Xing.,Li, He.,Jia, Yanxia.,...&Li, Weiqi.(2024).Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content.FUNGAL BIOLOGY,128(7),2190-2196.
MLA	Gao, Bo,et al."Cadmium and calcium ions' effects on the growth of Pleurotus ostreatus mycelia are related to phosphatidylethanolamine content".FUNGAL BIOLOGY 128.7(2024):2190-2196.

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