Isospongian Diterpenoids from the Leaves of Amomum tsao-ko Promote GLP-1 Secretion via Ca2+/CaMKII and PKA Pathways and Inhibit DPP-4 Enzyme

doi:10.1002/cbdv.202401407

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	Isospongian Diterpenoids from the Leaves of Amomum tsao-ko Promote GLP-1 Secretion via Ca2+/CaMKII and PKA Pathways and Inhibit DPP-4 Enzyme
	Wang, Yun; Wu, Sheng-Li; Li, Xin-Yu; Gongpan, Pianchou; Fu, Hang; Liao, Xiang-Ming; Yang, Yi; Huang, Mei; Huang, Xiao-Yan; Ma, Yun-Bao; Li, Da-Hong; Geng, Chang-An
	2024
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	21 期号:11 页码:e202401407
摘要	Three uncommon isospongian diterpenoids including a new one, 3-epi-kravanhin A (2), were isolated from the leaves of Amomum tsao-ko. Compounds 2 and 3 dose-dependently promoted GLP-1 secretion on STC-1 cells with promotion ratios of 109.7 % and 186.1 % (60 mu M). Mechanism study demonstrated that the GLP-1 stimulative effects of 2 and 3 were closely related with Ca2+/CaMKII and PKA pathways, but irrelevant to GPBAR1 and GPR119 receptors. Moreover, compound 1 showed DPP-4 inhibitory activity with an IC50 value of 311.0 mu M. Molecular docking verified the binding affinity of 1 with DPP-4 by hydrogen bonds between the gamma-lactone carbonyl (C-15) and Arg61 residue. Bioinformatics study indicated that compound 1 exerted antidiabetic effects by improving inflammation, oxidative stress and insulin resistance. This study first disclosed the presence of isospongian diterpenoids in A. tsao-ko, which showed antidiabetic potency by promoting GLP-1 secretion and inhibiting DPP-4 activity.
DOI	10.1002/cbdv.202401407
WOS记录号	WOS:001357985200017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76176
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Yun,Wu, Sheng-Li,Li, Xin-Yu,et al. Isospongian Diterpenoids from the Leaves of Amomum tsao-ko Promote GLP-1 Secretion via Ca2+/CaMKII and PKA Pathways and Inhibit DPP-4 Enzyme[J]. CHEMISTRY & BIODIVERSITY,2024,21(11):e202401407.
APA	Wang, Yun.,Wu, Sheng-Li.,Li, Xin-Yu.,Gongpan, Pianchou.,Fu, Hang.,...&Geng, Chang-An.(2024).Isospongian Diterpenoids from the Leaves of Amomum tsao-ko Promote GLP-1 Secretion via Ca2+/CaMKII and PKA Pathways and Inhibit DPP-4 Enzyme.CHEMISTRY & BIODIVERSITY,21(11),e202401407.
MLA	Wang, Yun,et al."Isospongian Diterpenoids from the Leaves of Amomum tsao-ko Promote GLP-1 Secretion via Ca2+/CaMKII and PKA Pathways and Inhibit DPP-4 Enzyme".CHEMISTRY & BIODIVERSITY 21.11(2024):e202401407.

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