Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata.

doi:10.1007/s13659-024-00476-6

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	Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata.
	Huang, Ni; Yang, Yi-Na; Huang, Jia; Shao, Hui-Yan; Li, Yan-Lang; Qin, Shi-Hui; Li, Han-Fen; Shen, Xiao-Jiang; Yang, Liu; Hu, Jiang-Miao
	2024
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	14 期号:1 页码:52-52
摘要	Dictyophora rubrovalvata is a valuable fungus homologous to food and medicine, and its polysaccharide have been gaining increasing attention because of its plentiful activity. However, the structure and activity of its homogeneous polysaccharide have not been studied enough. In this study, two polysaccharides DRP-I and DRP-II were purified from D. rubrovalvata. Their structures were characterized by chemical composition, monosaccharide composition analysis, methylation analysis and nuclear magnetic resonance spectroscopy. The results showed that DRP-I and DRP-II were neutral heteropolysaccharides with molecular weights of 5.79103 and 1.25104Da, respectively, which were composed of mannose, galactose, glucose, xylose and fucose. The main chains were6)-alpha-D-Galp-(16)-alpha-D-Galp-(2,16)-alpha-D-Manp-(2,16)-alpha-D-Galp-(1, and branch chains were beta-D-Xylp-(13)-alpha-L-Fucp-(14)-alpha-D-Manp-(1and alpha-D-Galp-(13)-alpha-D-Galp-(1. The in vitro immunoactivity assays on dendritic cells showed that DRP-I and DRP-II could up-regulate the expression of IL-10 and IL-6 and inhibit the expression of TNF-alpha in a concentration-dependent manner. This research indicated that DRP-I and DRP-II possessed immunoactivity by balancing the excessive inflammation, and molecular weight is an important factor affecting immunoactivity.
DOI	10.1007/s13659-024-00476-6
WOS记录号	MEDLINE:39276254
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76117
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Huang, Ni,Yang, Yi-Na,Huang, Jia,et al. Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata.[J]. Natural products and bioprospecting,2024,14(1):52-52.
APA	Huang, Ni.,Yang, Yi-Na.,Huang, Jia.,Shao, Hui-Yan.,Li, Yan-Lang.,...&Hu, Jiang-Miao.(2024).Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata..Natural products and bioprospecting,14(1),52-52.
MLA	Huang, Ni,et al."Structure characterization and immunoactivity on dendritic cells of two neutral polysaccharides from Dictyophora rubrovalvata.".Natural products and bioprospecting 14.1(2024):52-52.

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