Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis

doi:10.1016/j.biopha.2024.117087

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	Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis
	Xiao, Longgao; Yan, Huan; Yang, Songxue; Liu, Hui; Li, Yanxi; Fang, Xin; Ni, Wei; Zhang, Xingjie; Xiao, Weilie; Liu, Haiyang
	2024
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	177 页码:117087
摘要	Thirteen previously undescribed lindenane sesquiterpenoid dimers (LSDs), named chlorahololides G-S (1-13), were isolated from the whole plants of Chloranthus holostegius var. shimianensis, along with ten known analogues (14-23). The structures and absolute configurations of compounds 1-13 were elucidated through comprehensive spectroscopic analysis, NMR and electronic circular dichroism (ECD) calculations, and X-ray single-crystal diffraction. Chlorahololide G (1) represents the first instance of LSDs formed via a C-15-C-9 ' carbon-carbon single bond, whose plausible biosynthetic pathway was also proposed. Chlorahololides I and J (3 and 4) were deduced to be rare 8,9-seco and 9-deoxy LSDs with C-11-C-7 ' carbon-carbon bond, respectively. The inhibitory activity against NLRP3 inflammasome activation was evaluated for all isolates, with six compounds (5, 7, 8, 17, 22, and 23) exhibiting significant effects, and IC50 values ranging from 2.99 to 8.73 mu M. Additionally, a preliminary structure-activity relationship analysis regarding their inhibition of NLRP3 inflammasome activation was summarized. Compound 17 exhibited dose-dependent inhibition of nigericin-induced pyroptosis in J774A.1 cells. Molecular docking studies suggested a strong interaction between compound 17 and NLRP3.
DOI	10.1016/j.biopha.2024.117087
WOS记录号	WOS:001265441600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76111
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xiao, Longgao,Yan, Huan,Yang, Songxue,et al. Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,177:117087.
APA	Xiao, Longgao.,Yan, Huan.,Yang, Songxue.,Liu, Hui.,Li, Yanxi.,...&Liu, Haiyang.(2024).Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis.BIOMEDICINE & PHARMACOTHERAPY,177,117087.
MLA	Xiao, Longgao,et al."Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis".BIOMEDICINE & PHARMACOTHERAPY 177(2024):117087.

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