A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity

doi:10.1016/j.jinorgbio.2024.112721

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	A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity
	Wang, Kehua; Wang, Ling; Shang, Zhuye; Yang, Xingzhi; Li, Hongmei; Wang, Xiaochun; Zhu, Mingchang; Meng, Qingtao
	2024
发表期刊	JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN	0162-0134
卷号	261 页码:112721
摘要	Copper(II) complexes are very promising candidates for platinum-based anticancer agents. Herein, three Cu (II) complexes (1-3) containing 1,8-naphthalimide ligands were synthesized and characterized by FT-IR, elemental analysis, ESI-MS and single crystal X-ray diffraction (complex 3). In addition, a control compound (complex 4) without 1,8-naphthalimide ligand was synthesized and characterized. The in vitro anticancer activity of the synthesized complexes against five cancer cell lines and one normal cell line was evaluated by MTS assay. The results displayed the antitumor activity of complexes 1-3 was controlled by the aliphatic chain length of ligands, their cytotoxicity was in the order 3 > 2 > 1, giving the IC50 values ranging from 2.874 +/- 0.155 mu M to 31.47 +/- 0.29 mu M against five cancer cell lines. Complex 4 showed less activity in comparison with complex 1-3. Notably, complexes 1-3 displayed much higher selectivity (SI = 2.65 to 10.16) compared to complex 4 (SI = 1.0), indicated that the introduction of 1,8-naphthalimide group not only increased the activity of this series of compounds but also enhanced their specific selectivity to cancer cells. Compound 3 induced apoptosis in cancer cells and blocked the S-phase and G2/M of cancer cells. The interaction with DNA of complexes 3 and 4 was studied by UV/Vis spectroscopic titrations, competitive DNA-binding experiment, viscometry and CD spectra. The results showed that complex 3 interacted with DNA in an intercalating mode, but the interaction mode of compound 4 with DNA was electrostatic interaction.
DOI	10.1016/j.jinorgbio.2024.112721
WOS记录号	WOS:001308728500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76067
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Kehua,Wang, Ling,Shang, Zhuye,et al. A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2024,261:112721.
APA	Wang, Kehua.,Wang, Ling.,Shang, Zhuye.,Yang, Xingzhi.,Li, Hongmei.,...&Meng, Qingtao.(2024).A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity.JOURNAL OF INORGANIC BIOCHEMISTRY,261,112721.
MLA	Wang, Kehua,et al."A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity".JOURNAL OF INORGANIC BIOCHEMISTRY 261(2024):112721.

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