6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria

doi:10.1021/acsinfecdis.4c00571

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	6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria
	Bai, Li-Yu; Wang, Zhao-Jie; Lu, Qing-Yu; Huang, Huan; Zhu, Yan-Yan; Zhao, Yun-Li; Luo, Xiao-Dong
	2024
发表期刊	ACS INFECTIOUS DISEASES
ISSN	2373-8227
卷号	10 期号:9 页码:3430-3439
摘要	Vancomycin-resistant enterococcus (VRE) is a major nosocomial pathogen that exhibits enhanced infectivity due to its robust virulence and biofilm-forming capabilities. In this study, 6-methoxyldihydrochelerythrine chloride (6-MDC) inhibited the growth of exponential-phase VRE and restored VRE's sensitivity to vancomycin. 6-MDC predominantly suppressed the de novo biosynthetic pathway of pyrimidine and purine in VRE by the RNA-Seq analysis, resulting in obstructed DNA synthesis, which subsequently weakened bacterial virulence and impeded intracellular survival. Furthermore, 6-MDC inhibited biofilm formation, eradicated established biofilms, reduced virulence, and enhanced the host immune response to prevent intracellular survival and replication of VRE. Finally, 6-MDC reduced the VRE load in peritoneal fluid and cells significantly in a murine peritoneal infection model. This paper provides insight into the potential antimicrobial target of benzophenanthridine alkaloids for the first time.
DOI	10.1021/acsinfecdis.4c00571
WOS记录号	WOS:001299066100001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76010
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Bai, Li-Yu,Wang, Zhao-Jie,Lu, Qing-Yu,et al. 6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria[J]. ACS INFECTIOUS DISEASES,2024,10(9):3430-3439.
APA	Bai, Li-Yu.,Wang, Zhao-Jie.,Lu, Qing-Yu.,Huang, Huan.,Zhu, Yan-Yan.,...&Luo, Xiao-Dong.(2024).6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria.ACS INFECTIOUS DISEASES,10(9),3430-3439.
MLA	Bai, Li-Yu,et al."6-Methoxyldihydrochelerythrine Chloride Inhibiting Intra and Extracellular Drug-Resistant Bacteria".ACS INFECTIOUS DISEASES 10.9(2024):3430-3439.

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