Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease

doi:10.3389/fphar.2024.1426569

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	Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease
	Yang, Meixia; Yan, Caishan; Ospondpant, Dusadee; Wang, Lisong; Lin, Shengying; Tang, Wai Lun; Dong, Tina Tingxia; Tong, Penger; Xu, Qin; Tsim, Karl Wah Keung
	2024
发表期刊	FRONTIERS IN PHARMACOLOGY
卷号	15 页码:1426569
摘要	Background: The development of effective inhibitors that can inhibit amyloid beta (A beta) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment of Alzheimer's disease (AD). Lobaria (Schreb.) Hoffm., a traditional Chinese medicine used in Himalaya region for inflammatory diseases, contains depsides/depsidones (DEPs) such as gyrophoric acid, norstictic acid, and stictic acid known for their anti-cancer and anti-inflammation properties. Methods: Lobaria extracts were analyzed using HPLC to identify DEPs and establish standards. The inhibitory effects of Lobaria on A beta 42 fibrillization and depolymerization were assessed using various approaches with biophysical and cellular methods. The neuroprotective activity of Lobaria extracts and its DEPs aganist A beta-mediated cytotoxicity was also evaluated. Results: Norstictic and stictic acid were found in the water extract, while norstictic, stictic, and gyrophoric acid were detected in the ethanol extract of Lobaria. Both extracts, and their DEPs effectively inhibited A beta 42 fibrillation and disaggregate mature A beta 42 fibrils. Notably, the ethanol extract showed superior inhibitory effect compared to the water extract, with gyrophoric acid being the most effective DEPs. Additionally, herbal extract-treated A beta 42 aggregation species significantly protected neuronal cells from A beta 42-induced cell damage and promoted neurite outgrowth. Conclusion: This study is the first to investigate the effect of Lobaria on A beta 42 and neuronal cell in AD. Given that Lobaria is commonly used in ethnic medicine and food with good safety records, our findings propose that Lobaria extracts and DEPs have potential as neuroprotective and therapeutic agents for AD patients.
DOI	10.3389/fphar.2024.1426569
WOS记录号	WOS:001298615800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75832
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang, Meixia,Yan, Caishan,Ospondpant, Dusadee,et al. Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease[J]. FRONTIERS IN PHARMACOLOGY,2024,15:1426569.
APA	Yang, Meixia.,Yan, Caishan.,Ospondpant, Dusadee.,Wang, Lisong.,Lin, Shengying.,...&Tsim, Karl Wah Keung.(2024).Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease.FRONTIERS IN PHARMACOLOGY,15,1426569.
MLA	Yang, Meixia,et al."Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease".FRONTIERS IN PHARMACOLOGY 15(2024):1426569.

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