Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco

doi:10.3389/fpls.2024.1338169

KIB OpenIR

	Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco
	Song, Zhongbang; Wang, Ruixue; Zhang, Hongbo; Tong, Zhijun; Yuan, Cheng; Li, Yong; Huang, Changjun; Zhao, Lu; Wang, Yuehu; Di, Yingtong; Sui, Xueyi
	2024
发表期刊	FRONTIERS IN PLANT SCIENCE
ISSN	1664-462X
卷号	15 页码:1338169
摘要	The pyridine alkaloid nicotine acts as one of best-studied plant resistant traits in tobacco. Previous research has shown that NtERF199 and NtERF189, acting as master regulators within the NIC1 and NIC2 locus, quantitatively contribute to nicotine accumulation levels in N. tabacum. Genome editing-created Nic1(Nterf199) and Nic2 (Nterf189) double mutant provides an ideal platform for precisely dissecting the defensive role of nicotine and the connection between the nicotine biosynthetic pathway with other putative metabolic networks. Taking this advantage, we performed a comparative transcriptomic analysis to reevaluate the potential physiological and metabolic changes in response to nicotine synthesis defect by comparing the nic1nic2 and NIC1NIC2 plants. Our findings revealed that nicotine reduction could systematically diminishes the expression intensities of genes associated with stimulus perception, signal transduction and regulation, as well as secondary metabolic flux. Consequently, this global expression reduction might compromise tobacco adaptions to environmental fitness, herbivore resistances, and plant growth and development. The up-regulation of a novel set of stress-responsive and metabolic pathway genes might signify a newly established metabolic reprogramming to tradeoff the detrimental effect of nicotine loss. These results offer additional compelling evidence regarding nicotine's critical defensive role in nature and highlights the tight link between nicotine biosynthesis and gene expression levels of quantitative resistance-related genes for better environmental adaptation.
DOI	10.3389/fpls.2024.1338169
WOS记录号	WOS:001198697200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75829
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Song, Zhongbang,Wang, Ruixue,Zhang, Hongbo,et al. Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco[J]. FRONTIERS IN PLANT SCIENCE,2024,15:1338169.
APA	Song, Zhongbang.,Wang, Ruixue.,Zhang, Hongbo.,Tong, Zhijun.,Yuan, Cheng.,...&Sui, Xueyi.(2024).Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco.FRONTIERS IN PLANT SCIENCE,15,1338169.
MLA	Song, Zhongbang,et al."Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco".FRONTIERS IN PLANT SCIENCE 15(2024):1338169.

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10.3389_fpls.2024.13（5547KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载