Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy

doi:10.3390/fermentation10110559

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	Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy
	Zhang, Xiang; Wei, Qiulin; Tian, Liwen; Huang, Zhixian; Tang, Yanbo; Wen, Yongdi; Yu, Fuqiang; Yan, Xiaoxiao; Zhao, Yunchun; Wu, Zhenqiang; Tian, Xiaofei
	2024
发表期刊	FERMENTATION-BASEL
卷号	10 期号:11 页码:559
摘要	Hypocrellins (HYPs), naturally occurring 3,10-xylene-4,9-anthracene derivatives sourced from Shiraia bambusicola and Hypocrella bambusae, exhibit significant photobiological activities. Despite their capability for generating a high yield of reactive oxygen species, including singlet oxygen and superoxide anion radical, their application in photodynamic therapy (PDT) is constrained. This limitation is due to their low dark phototoxicity, weak absorption within the therapeutic window of PDT (600-900 nm), and inherent hydrophobicity, which hinder their immediate use in amphipathic PDT applications. This review comprehensively discusses the research advancements in the bioactivities and biosynthesis of HYPs, alongside the reported chemical and physical modifications that enhance their water solubility and extend their therapeutic window. Additionally, it explores potential strategies for developing pharmaceuticals, photocatalytic agents, and photosensitive pesticides based on HYPs.
DOI	10.3390/fermentation10110559
WOS记录号	WOS:001365095400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75805
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang, Xiang,Wei, Qiulin,Tian, Liwen,et al. Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy[J]. FERMENTATION-BASEL,2024,10(11):559.
APA	Zhang, Xiang.,Wei, Qiulin.,Tian, Liwen.,Huang, Zhixian.,Tang, Yanbo.,...&Tian, Xiaofei.(2024).Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy.FERMENTATION-BASEL,10(11),559.
MLA	Zhang, Xiang,et al."Advancements and Future Prospects in Hypocrellins Production and Modification for Photodynamic Therapy".FERMENTATION-BASEL 10.11(2024):559.

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