6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor

doi:10.3390/ijms25020972

KIB OpenIR

	6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor
	Xie, Dong; Fu, Wengan; Yuan, Tiantian; Han, Kangjia; Lv, Yuxiu; Wang, Qi; Jiang, Qian; Zhang, Yingjun; Zhu, Guolei; Xu, Junming; Zhao, Ping; Yang, Xiaoqin
	2024
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1661-6596
卷号	25 期号:2 页码:972
摘要	Tyrosinase is vital in fruit and vegetable browning and melanin synthesis, crucial for food preservation and pharmaceuticals. We investigated 6 '-O-caffeoylarbutin's inhibition, safety, and preservation on tyrosinase. Using HPLC, we analyzed its effect on mushroom tyrosinase and confirmed reversible competitive inhibition. UV_vis and fluorescence spectroscopy revealed a stable complex formation with specific binding, causing enzyme conformational changes. Molecular docking and simulations highlighted strong binding, enabled by hydrogen bonds and hydrophobic interactions. Cellular tests showed growth reduction of A375 cells with mild HaCaT cell toxicity, indicating favorable safety. Animal experiments demonstrated slight toxicity within safe doses. Preservation trials on apple juice showcased 6 '-O-caffeoylarbutin's potential in reducing browning. In essence, this study reveals intricate mechanisms and applications of 6 '-O-caffeoylarbutin as an effective tyrosinase inhibitor, emphasizing its importance in food preservation and pharmaceuticals. Our research enhances understanding in this field, laying a solid foundation for future exploration.
DOI	10.3390/ijms25020972
WOS记录号	WOS:001152802400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75795
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xie, Dong,Fu, Wengan,Yuan, Tiantian,等. 6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(2):972.
APA	Xie, Dong.,Fu, Wengan.,Yuan, Tiantian.,Han, Kangjia.,Lv, Yuxiu.,...&Yang, Xiaoqin.(2024).6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(2),972.
MLA	Xie, Dong,et al."6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.2(2024):972.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.3390_ijms25020972（7255KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载