Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans

doi:10.3390/metabo14010049

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	Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans
	Yan, Lili; Deng, Yuchan; Du, Yulan; Fang, Xutong; Fang, Xin; Zhang, Qiang
	2024
发表期刊	METABOLITES
卷号	14 期号:1 页码:49
摘要	Smilax china L. (Chinaroot) is a natural herb that has multiple uses, such as being used to make tea and food. Both its roots and leaves have different uses due to their unique components. In this study, we analyzed the extract of S. china. roots using LC-HRMS and evaluated the neuroprotective effects and metabolic regulation of S. china on Caenorhabditis elegans. Chinaroot extract prolonged the life span of healthy nematodes, delayed the paralysis time of transgenic CL4176, and reduced the level of beta-amyloid deposition in transgenic CL2006. The comprehensive analysis of metabolomics and qRT-PCR revealed that Chinaroot extract exerted neuroprotective effects through the valine, leucine and isoleucine degradation and fatty acid degradation pathways. Moreover, we first discovered that the expressions of T09B4.8, ech-7, and agxt-1 were linked to the neuroprotective effects of Chinaroot. The material exerted neuroprotective effects by modulating metabolic abnormalities in AD model C. elegans. Our study provides a new foundation for the development of functional food properties and functions.
DOI	10.3390/metabo14010049
WOS记录号	WOS:001152919600001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75783
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yan, Lili,Deng, Yuchan,Du, Yulan,et al. Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans[J]. METABOLITES,2024,14(1):49.
APA	Yan, Lili,Deng, Yuchan,Du, Yulan,Fang, Xutong,Fang, Xin,&Zhang, Qiang.(2024).Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans.METABOLITES,14(1),49.
MLA	Yan, Lili,et al."Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans".METABOLITES 14.1(2024):49.

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