The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

doi:10.3389/fphar.2022.874474

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	The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance
	Arunachalam, Karuppusamy; Sreeja, Puthanpura Sasidharan; Yang, Xuefei
	2022
发表期刊	FRONTIERS IN PHARMACOLOGY
卷号	13 页码:874474
摘要	Diabetes mellitus is a prevalent metabolic and endocrine illness affecting people all over the world and is of serious health and financial concern. Antidiabetic medicine delivered through pharmacotherapy, including synthetic antidiabetic drugs, are known to have several negative effects. Fortunately, several natural polysaccharides have antidiabetic properties, and the use of these polysaccharides as adjuncts to conventional therapy is becoming more common, particularly in underdeveloped nations. Oxidative stress has a critical role in the development of diabetes mellitus (DM). The review of current literature presented here focusses, therefore, on the antioxidant properties of mushroom polysaccharides used in the management of diabetic complications, and discusses whether these antioxidant properties contribute to the deactivation of the oxidative stress-related signalling pathways, and to the amelioration of beta-cell dysfunction and insulin resistance. In this study, we conducted a systematic review of the relevant information concerning the antioxidant and antidiabetic effects of mushrooms from electronic databases, such as PubMed, Scopus or Google Scholar, for the period 1994 to 2021. In total, 104 different polysaccharides from mushrooms have been found to have antidiabetic effects. Most of the literature on mushroom polysaccharides has demonstrated the beneficial effects of these polysaccharides on reactive oxygen and nitrogen species (RONS) levels. This review discuss the effects of these polysaccharides on hyperglycemia and other alternative antioxidant therapies for diabetic complications through their applications and limits, in order to gain a better understanding of how they can be used to treat DM. Preclinical and phytochemical investigations have found that most of the active polysaccharides extracted from mushrooms have antioxidant activity, reducing oxidative stress and preventing the development of DM. Further research is necessary to confirm whether mushroom polysaccharides can effectively alleviate hyperglycemia, and the mechanisms by which they do this, and to investigate whether these polysaccharides might be utilized as a complementary therapy for the prevention and management of DM in the future.
关键词	reactive oxygen species oxidative stress antioxidant diabetes mellitus mushroom polysaccharides AGARICUS-BLAZEI MURILL GANODERMA-LUCIDUM POLYSACCHARIDES ACTIVATED SIGNALING PATHWAYS TYPE-2 DIABETES-MELLITUS PROTEIN-KINASE-C MT-ALPHA-GLUCAN MEDICINAL MUSHROOM SUBMERGED-CULTURE PHELLINUS-LINTEUS STRUCTURAL-CHARACTERIZATION
DOI	10.3389/fphar.2022.874474
收录类别	SCI
WOS记录号	WOS:000797932500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75642
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Arunachalam, Karuppusamy,Sreeja, Puthanpura Sasidharan,Yang, Xuefei. The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance[J]. FRONTIERS IN PHARMACOLOGY,2022,13:874474.
APA	Arunachalam, Karuppusamy,Sreeja, Puthanpura Sasidharan,&Yang, Xuefei.(2022).The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance.FRONTIERS IN PHARMACOLOGY,13,874474.
MLA	Arunachalam, Karuppusamy,et al."The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance".FRONTIERS IN PHARMACOLOGY 13(2022):874474.

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