Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants

doi:10.1055/a-2072-2177

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	Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants
	Li,Junheng; Chen,Yin; Wu,Lei; Tuo,Xiaotao; Wang,Li; Zhou,Guanglian; Huang,Sheng-Xiong; Xiong,Wei; Huang,Jian-Ping
	2023
发表期刊	PLANTA MEDICA
ISSN	1439-0221
卷号	89 期号:13 页码:1250-1258
摘要	Camptothecin (CPT) and its derivatives have attracted worldwide attention because of their notable anticancer activity. However, the growing demand for CPT in the global pharmaceutical industry has caused a severe shortage of CPT-producing plant resources. In this study, phytochemical analysis of Nothapodytes tomentosa results in the isolation and identification of CPT ( 13 ) and 16 analogues ( 1 - 12, 14 - 17 ), including a new ( 1 ) and five known ( 9, 10, 12, 15 , and 17 ) CPT analogues with an open E-ring. In view of the potential anticancer activity of CPT analogues with an open E-ring, the fragmentation pathways and mass spectra profiles of these six CPT analogues ( 1, 9, 10, 12, 15 , and 17 ) are investigated, providing a reference for the rapid detection of these compounds in other plants. Furthermore, based on the fragmentation patterns of CPT ( 13 ) and known analogues ( 2 - 8, 11, 14, 16, 18 - 26 ), the distribution and content of these compounds in different tissues of N. tomentosa, N. nimmoniana, Camptotheca acuminata , and Ophiorrhiza japonica are further studied. Our findings not only provide an alternative plant resource for further expanding the development and utilization of CPT and its analogues, but also lay a foundation for improving the utilization of known CPT-producing plant resources.
关键词	Nothapodytes tomentosa Nothapodytes nimmoniana Camptotheca acuminata Ophiorrhiza japonica Icacinaceae camptothecin derivatives ANTITUMOR AGENTS ACID-ESTER 9-METHOXYCAMPTOTHECIN IDENTIFICATION CONSTITUENTS ALKALOIDS MEDICINE FRUITS
DOI	10.1055/a-2072-2177
收录类别	SCI
WOS记录号	WOS:001039281300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75604
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li,Junheng,Chen,Yin,Wu,Lei,et al. Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants[J]. PLANTA MEDICA,2023,89(13):1250-1258.
APA	Li,Junheng.,Chen,Yin.,Wu,Lei.,Tuo,Xiaotao.,Wang,Li.,...&Huang,Jian-Ping.(2023).Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants.PLANTA MEDICA,89(13),1250-1258.
MLA	Li,Junheng,et al."Phytochemical Analysis of Nothapodytes tomentosa and Distribution and Content of Camptothecin and its Analogues in Four Plants".PLANTA MEDICA 89.13(2023):1250-1258.

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