The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B

doi:10.1016/j.indcrop.2023.116499

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	The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B
	Xiao,Xia; Liu,Yang-Yang; Yan,Xiao-Jun; Wang,Xiao-Na; Hu,Bin-Yuan; Chen,Song; Zhu,Yan-Yan; Wang,Zhao-Jie; Xie,Tian-Zhen; He,Ying-Jie; Zhao,Li-Xing; Zhao,Yun-Li; Luo,Xiao-Dong
	2023
发表期刊	INDUSTRIAL CROPS AND PRODUCTS
ISSN	1872-633X
卷号	196 页码:116499
摘要	Allium chinense G. Don is a popular medicinal and aromatic plant, known as Ganoderma of vegetables in history for treating blood stasis syndrome that reduces red blood cell oxygen-carrying capacity and often causes severe brain damage. However, the effect of A. chinense on cerebral anoxia remains obscure. Here, the anti-hypoxic effect of A. chinense was investigated for the first time through the cerebral anoxia model of mice. Subsequent a bio-guided investigation brought about the isolation of 16 compounds, including 9 phenolic derivatives (2 new compounds (compound 1, 8) and one new natural product (compound 2), 4 steroidal saponins and 3 fatty acid monoglycerides, among which, 6 compounds (1-4, 7, 16) exhibited significant anoxia-tolerant activity in vitro. Moreover, the release of reactive oxygen species (ROS) was decreased significantly, and glutathione (GSH) and lactate dehydrogenase (LDH) were regulated by the 6 bioactive compounds in oxygen-glucose deprivation/ reoxygenation (OGD/R)-induced BV-2 cells damage. Besides that, protein expressions of HIF-1 alpha, NLRP3, COX-2, NF-kappa B p65 and IL-18 were suppressed effectively. The investigation provided a new nutritional strategy for A. chinense against cerebral anoxia and altitude illness, which might be partially mediated by downregulating NLRP3/NF-kappa B.
关键词	Allium chinense Cerebral anoxia Intracellular reactive oxygen species NLRP3 NF-?B Nutritional strategy ACID MITOCHONDRIA CONTRIBUTES METALATION INHIBITORS SAPONINS DAMAGE
学科领域	Agriculture
DOI	10.1016/j.indcrop.2023.116499
收录类别	SCI
WOS记录号	WOS:000953271900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75570
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xiao,Xia,Liu,Yang-Yang,Yan,Xiao-Jun,et al. The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B[J]. INDUSTRIAL CROPS AND PRODUCTS,2023,196:116499.
APA	Xiao,Xia.,Liu,Yang-Yang.,Yan,Xiao-Jun.,Wang,Xiao-Na.,Hu,Bin-Yuan.,...&Luo,Xiao-Dong.(2023).The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B.INDUSTRIAL CROPS AND PRODUCTS,196,116499.
MLA	Xiao,Xia,et al."The protective effect of Allium chinense on anti-cerebral anoxia through regulating NLRP3/NF-?B".INDUSTRIAL CROPS AND PRODUCTS 196(2023):116499.

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