Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity

doi:10.1016/j.phytochem.2023.113823

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	Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity
	Ren,Xue; Yuan,Xin; Jiao,Shan-Shan; He,Xiao-Ping; Hu,Hong; Kang,Juan-Juan; Luo,Shi-Hong; Liu,Yan; Guo,Kai; Li,Sheng-Hong
	2023
发表期刊	PHYTOCHEMISTRY
ISSN	1873-3700
卷号	214 页码:113823
摘要	Six undescribed clerodane diterpenoids along with five known ones were isolated from the aerial parts of Salvia deserta, a traditional Uygur medicine. Their chemical structures including absolute configurations were elucidated by extensive spectroscopic analysis (including 1D and 2D NMR, HRESIMS, and IR), combined with calculated ECD method and single-crystal X-ray diffraction analysis. All the compounds possessed a terminal & alpha;,& beta;-unsaturated-& gamma;-lactone moiety, and were assayed for their immunosuppressive activity via inhibiting the secretion of cytokines TNF-& alpha; and IL-6 in macrophages RAW264.7. Among them, (5R,8R,9S,10R)-18-nor-cleroda-2,13-dien-16,15-olide-4-one obviously suppressed the secretion of TNF-& alpha; and IL-6 with IC50 values of 8.55 and 13.65 & mu;M, respectively.
关键词	Salvia deserta Lamiaceae Clerodane diterpenoids Chemical constituents ROOTS
DOI	10.1016/j.phytochem.2023.113823
收录类别	SCI
WOS记录号	WOS:001065959200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75525
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Ren,Xue,Yuan,Xin,Jiao,Shan-Shan,et al. Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity[J]. PHYTOCHEMISTRY,2023,214:113823.
APA	Ren,Xue.,Yuan,Xin.,Jiao,Shan-Shan.,He,Xiao-Ping.,Hu,Hong.,...&Li,Sheng-Hong.(2023).Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity.PHYTOCHEMISTRY,214,113823.
MLA	Ren,Xue,et al."Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity".PHYTOCHEMISTRY 214(2023):113823.

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