Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities

doi:10.1016/j.fitote.2022.105356

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	Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities
	Jin,Qiong; Qin,Xu-Jie; Dai,Zhi; Zhao,Yun; Zhu,Yan-Yan; Chen,Shan-Shan; Liu,Ya-Ping; Luo,Xiao-Dong
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	164 页码:105356
摘要	A phytochemical investigation of the whole plants of T. delavayi led to the isolation of five new dimeric ben-zylisoquinoline alkaloids, thalidelavines A-E (1-5), together with six known congeners (6-11). The structures and absolute configurations of new compounds were established based on analyses of spectroscopic data, ECD calculations, and single crystal X-ray crystallography. Thalidelavines A-E (1-5) were structurally complex bis-benzylisoquinoline alkaloids with various configurations. These isolated alkaloids were evaluated for their cytotoxic and immunosuppressive effects. Among them, both 9 and 10 displayed significant cytotoxicities against T98G cell lines with an IC50 value of 2.1 mu M, compared with the positive CPT-11 (IC50 = 3.0 mu M). In addition, 5-7 showed remarkable immunosuppressive effects. These findings not only enrich the structural diversity of bisbenzylisoquinoline alkaloids, but also provide potential candidates for the further development of the anti-tumor and immunosuppressive agents.
关键词	Thalictrum delavayi Ranunculaceae Bisbenzylisoquinoline alkaloids Cytotoxicities Immunosuppressive effects CYCLOARTANE GLYCOSIDES APORPHINE LEAVES PLANTS
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2022.105356
收录类别	SCI
WOS记录号	WOS:000895484400008
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75522
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Jin,Qiong,Qin,Xu-Jie,Dai,Zhi,et al. Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities[J]. FITOTERAPIA,2023,164:105356.
APA	Jin,Qiong.,Qin,Xu-Jie.,Dai,Zhi.,Zhao,Yun.,Zhu,Yan-Yan.,...&Luo,Xiao-Dong.(2023).Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities.FITOTERAPIA,164,105356.
MLA	Jin,Qiong,et al."Dimeric benzylisoquinoline alkaloids from Thalictrum delavayi and their biological activities".FITOTERAPIA 164(2023):105356.

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