Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity

doi:10.1016/j.fitote.2022.105399

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	Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity
	Wang,Yuan; Ma,Yun-Bao; Huang,Xiao-Yan; Li,Tian-Ze; He,Xiao-Feng; Zhang,Xue-Mei; Chen,Ji-Jun
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	165 页码:105399
摘要	Twelve undescribed and 13 known eudesmane-type sesquiterpenoids were obtained from Artemisia leucophylla, and structurally elucidated based on comprehensive analyses of spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculation. The absolute configuration of compound 1 was determined by a single X-ray single crystal diffraction. Chemically, compounds 1-5 featured unprecedented 1,2-seco-1-nor-eudesmane-type skeleton with a cis-fused 6/5 bicyclic system. Antihepatoma evaluation against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1) for all compounds demonstrated that compound 7 displayed the most active cytotoxicity with IC50 values of 35.1, 35.0, and 32.7 mu\M.
关键词	Artemisia leucophylla Artemleucolides A-L Eudesmane-type sesquiterpenoids Cytotoxicity ASSIGNMENT LACTONES
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2022.105399
收录类别	SCI
WOS记录号	WOS:000920065500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75520
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Yuan,Ma,Yun-Bao,Huang,Xiao-Yan,et al. Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity[J]. FITOTERAPIA,2023,165:105399.
APA	Wang,Yuan.,Ma,Yun-Bao.,Huang,Xiao-Yan.,Li,Tian-Ze.,He,Xiao-Feng.,...&Chen,Ji-Jun.(2023).Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity.FITOTERAPIA,165,105399.
MLA	Wang,Yuan,et al."Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity".FITOTERAPIA 165(2023):105399.

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