Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga

doi:10.1016/j.fitote.2023.105502

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	Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga
	Wang,Tian; Wu,Sheng-Li; Liu,Pei; Chen,Ji-Jun; Zhang,Xue-Mei; Geng,Chang-An
	2023
发表期刊	FITOTERAPIA
ISSN	1873-6971
卷号	167 页码:105502
摘要	Five new diarylheptanoids, kaemgalangins A-E (1-5), and seven known ones were isolated from the rhizomes of Kaempferia galanga. The structures of new compounds were identified by spectroscopic analyses involving 1D and 2D NMR, HRESIMS, IR, UV, [alpha]D, ECD calculations, and chemical methods. All compounds were tested for their hypoglycemic effects against alpha-glucosidase, Gpa and PTP1B enzymes, and stimulative effects on GLP-1 secretion. Kaemgalangins A (1) and E (5) showed significant inhibition on alpha-glucosidase with IC50 values of 45.3 and 116.0 mu M; renealtin B (8) showed inhibition on GPa with an IC50 value of 68.1 mu M; whereas all compounds were inactive to PTP1B. Docking study manifested that 1 well located in the catalytic pocket of alpha-glucosidase and OH-4 '' played important roles in maintaining activity. Moreover, all compounds showed obviously stimulative effects on GLP-1 with promoting rates of 826.9%-1738.3% in NCI-H716 cells. This study suggests that the diary-lheptanoids in K. galanga have antidiabetic potency by inhibiting alpha-glucosidase and Gpa enzymes, and promoting GLP-1 secretion.
关键词	Kaempferia galanga Diarylheptanoids ?-glucosidase and GPa inhibition GLP-1 promotion Antidiabetic effects INHIBITORS
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2023.105502
收录类别	SCI
WOS记录号	WOS:000982608400001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75512
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Tian,Wu,Sheng-Li,Liu,Pei,et al. Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga[J]. FITOTERAPIA,2023,167:105502.
APA	Wang,Tian,Wu,Sheng-Li,Liu,Pei,Chen,Ji-Jun,Zhang,Xue-Mei,&Geng,Chang-An.(2023).Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga.FITOTERAPIA,167,105502.
MLA	Wang,Tian,et al."Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga".FITOTERAPIA 167(2023):105502.

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