Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum

doi:10.1016/j.bioorg.2023.106553

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	Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum
	Liang,Yu; Liao,Hong; Chen,Xuanni; Wang,Qiwei; Li,Qin; Shen,Yong; Zheng,Yuyi; Li,Xiao-Nian; Zhu,Hucheng; Li,Dongyan; Sun,Weiguang; Chen,Chunmei; Zhang,Yonghui
	2023
发表期刊	BIOORGANIC CHEMISTRY
ISSN	1090-2120
卷号	136 页码:106553
摘要	Five new cyclopiazonic acid related indole alkaloids, pegriseofamines A-E (1-5), were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR, HRESIMS, quantum-chemical calculation, and X-ray diffraction experiments. Among them, pegriseofamine A (1) possesses an undescribed 6/5/6/7 tetracyclic ring system generated by the fusion of an azepine and an indole unit via a cyclohexane, and the postulated biosynthetic origin of 1 was discussed. Compound 4 could relieve liver injury and prevent hepatocyte apoptosis in ConA-induced autoimmune liver disease.
关键词	Penicillium griseofulvum Alkaloid Cyclopiazonic acid Immunosuppression activity
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1016/j.bioorg.2023.106553
收录类别	SCI
WOS记录号	WOS:000991729300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75476
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Liang,Yu,Liao,Hong,Chen,Xuanni,et al. Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum[J]. BIOORGANIC CHEMISTRY,2023,136:106553.
APA	Liang,Yu.,Liao,Hong.,Chen,Xuanni.,Wang,Qiwei.,Li,Qin.,...&Zhang,Yonghui.(2023).Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum.BIOORGANIC CHEMISTRY,136,106553.
MLA	Liang,Yu,et al."Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum".BIOORGANIC CHEMISTRY 136(2023):106553.

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