11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii

doi:10.1016/j.bioorg.2023.106834

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	11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii
	Xia,Fan; Lin,Li-Sha; Ye,Yan-Song; Yang,Lian; Zhao,Jin-Hua; Xu,Gang
	2023
发表期刊	BIOORGANIC CHEMISTRY
ISSN	1090-2120
卷号	140 页码:106834
摘要	Eleven new abietane-type diterpene lactones, salpratlactones D-N (1-11), including five 11,12-seco-11-nor- abietane diterpenes (1-5), four 11,12-seco-abietane diterpenes (6-9), two 20(10 -> 5)-abeo-4,5;11,12-bis-seco- abietane diterpenes (10-11), and two known analogues (12-13), were characterized from Salvia prattii. Notably, compounds 1-3 were characterized by a unique linear 6/6/6 tricyclic skeleton. The structures were established by spectroscopic data interpretation, calculated NMR-DP4+ and electronic circular dichroism analysis, as well as single-crystal X-ray diffraction. A bioactivity study showed that 1, 2, 5, 11, and 12 can potently inhibit platelet aggregation induced by arachidonic acid (AA), with IC50 values of 5.66-16.10 mu g/ml, stronger than aspirin. In addition, the lactate dehydrogenase assay showed that they had no effect on platelet integrity. Structurally, the same 1,2-benzopyrone fragments of 1, 2, and 5 should be the important pharmacophore for antiplatelet activity.
关键词	Salvia prattii 11 12 seco -Abietane-type diterpenes Antiplatelet activity
DOI	10.1016/j.bioorg.2023.106834
收录类别	SCI
WOS记录号	WOS:001076256600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75473
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Xia,Fan,Lin,Li-Sha,Ye,Yan-Song,et al. 11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii[J]. BIOORGANIC CHEMISTRY,2023,140:106834.
APA	Xia,Fan,Lin,Li-Sha,Ye,Yan-Song,Yang,Lian,Zhao,Jin-Hua,&Xu,Gang.(2023).11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii.BIOORGANIC CHEMISTRY,140,106834.
MLA	Xia,Fan,et al."11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii".BIOORGANIC CHEMISTRY 140(2023):106834.

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