Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis

doi:10.1039/d3qo00565h

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	Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis
	Wu,Zhaodi; Zhang,Xiaotian; Li,Qin; Tong,Qingyi; Yang,Jing; Chen,Chunmei; Zhu,Hucheng; Zhang,Yonghui
	2023
发表期刊	ORGANIC CHEMISTRY FRONTIERS
卷号	10 期号:14 页码:3530-3536
摘要	Amichalasines F-J (1-5), five new cytochalasan heterotrimers composed of two aspochalasins and one epicoccine unit, along with asperchalasine A (6), were isolated from Aspergillus micronesiensis. Their structures, including absolute configurations, were elucidated using extensive spectroscopic data, quantum chemical calculations, and single X-ray diffraction analyses. Compound 1 possesses a different fusion pattern between the aspochalasin and epicoccine unit compared with 6, resulting in a mirror-imaged epicoccine unit. Interestingly, compounds 2-4 also possess mirror-imaged core structures of 6, even though they have the same fusion pattern. Compounds 1, and 2-4 represent two new kinds of cytochalasan heterotrimers. Plausible biosynthetic pathways of 1-6 are proposed. Compounds 2-4 exhibited potent cytotoxic activities against six human cancer cell lines, and the IC50 values against HL60 ranged from 4.36 to 5.69 mu M.
关键词	ENDOPHYTIC FUNGUS RING-SYSTEM DIMER
学科领域	Chemistry
DOI	10.1039/d3qo00565h
收录类别	SCI
WOS记录号	WOS:001004961600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75435
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wu,Zhaodi,Zhang,Xiaotian,Li,Qin,et al. Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis[J]. ORGANIC CHEMISTRY FRONTIERS,2023,10(14):3530-3536.
APA	Wu,Zhaodi.,Zhang,Xiaotian.,Li,Qin.,Tong,Qingyi.,Yang,Jing.,...&Zhang,Yonghui.(2023).Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis.ORGANIC CHEMISTRY FRONTIERS,10(14),3530-3536.
MLA	Wu,Zhaodi,et al."Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis".ORGANIC CHEMISTRY FRONTIERS 10.14(2023):3530-3536.

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