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| Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis | |
Yuan,Xin; Yan,Qin; Hu,Hong ; He,Xiao-Ping; Wang,Li-Xia; Liu,Yan-Chun; Liu,Yan; Guo,Kai; Li,Sheng-Hong
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| 2023 | |
| Source Publication | PHYTOCHEMISTRY LETTERS
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| ISSN | 1876-7486 |
| Volume | 55Pages:1-5 |
| Abstract | Phytochemical investigation on the whole plant of Swertia mileensis led to the isolation of two new triterpenoids, including a 28-nor-oleanane (1) and a 3,4-seco-3-nor-oleanane (2), together with 21 known triterpenoids (3-23). Their structures were elucidated by extensive spectroscopic analysis. Compounds 2 and 10 exhibited antiinflammatory activity by inhibiting the secretion of cytokines TNF-alpha and IL-6 in RAW264.7 cells induced by LPS with IC50 values ranging from 32.8 to 69.8 mu M. Compounds 1 and 17 showed cytotoxicity against HepG2 and MDA-MB-231 cells with inhibitory rates ranging from 30.34 % to 47.18 % at 10 mu M. |
| Keyword | Swertia mileensis Gentianaceae Triterpenoids Anti-inflammatory activity Cytotoxicity |
| Subject Area | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.phytol.2023.03.001 |
| Indexed By | SCI |
| WOS ID | WOS:000951787000001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/75426 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Yuan,Xin,Yan,Qin,Hu,Hong,et al. Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis[J]. PHYTOCHEMISTRY LETTERS,2023,55:1-5. |
| APA | Yuan,Xin.,Yan,Qin.,Hu,Hong.,He,Xiao-Ping.,Wang,Li-Xia.,...&Li,Sheng-Hong.(2023).Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis.PHYTOCHEMISTRY LETTERS,55,1-5. |
| MLA | Yuan,Xin,et al."Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis".PHYTOCHEMISTRY LETTERS 55(2023):1-5. |
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| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S187439002300（592KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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