Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis

doi:10.1016/j.phytol.2023.03.001

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	Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis
	Yuan,Xin; Yan,Qin; Hu,Hong; He,Xiao-Ping; Wang,Li-Xia; Liu,Yan-Chun; Liu,Yan; Guo,Kai; Li,Sheng-Hong
	2023
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1876-7486
卷号	55 页码:1-5
摘要	Phytochemical investigation on the whole plant of Swertia mileensis led to the isolation of two new triterpenoids, including a 28-nor-oleanane (1) and a 3,4-seco-3-nor-oleanane (2), together with 21 known triterpenoids (3-23). Their structures were elucidated by extensive spectroscopic analysis. Compounds 2 and 10 exhibited antiinflammatory activity by inhibiting the secretion of cytokines TNF-alpha and IL-6 in RAW264.7 cells induced by LPS with IC50 values ranging from 32.8 to 69.8 mu M. Compounds 1 and 17 showed cytotoxicity against HepG2 and MDA-MB-231 cells with inhibitory rates ranging from 30.34 % to 47.18 % at 10 mu M.
关键词	Swertia mileensis Gentianaceae Triterpenoids Anti-inflammatory activity Cytotoxicity
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1016/j.phytol.2023.03.001
收录类别	SCI
WOS记录号	WOS:000951787000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75426
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yuan,Xin,Yan,Qin,Hu,Hong,et al. Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis[J]. PHYTOCHEMISTRY LETTERS,2023,55:1-5.
APA	Yuan,Xin.,Yan,Qin.,Hu,Hong.,He,Xiao-Ping.,Wang,Li-Xia.,...&Li,Sheng-Hong.(2023).Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis.PHYTOCHEMISTRY LETTERS,55,1-5.
MLA	Yuan,Xin,et al."Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis".PHYTOCHEMISTRY LETTERS 55(2023):1-5.

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