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Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis
Yuan,Xin; Yan,Qin; Hu,Hong; He,Xiao-Ping; Wang,Li-Xia; Liu,Yan-Chun; Liu,Yan; Guo,Kai; Li,Sheng-Hong
2023
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1876-7486
Volume55Pages:1-5
AbstractPhytochemical investigation on the whole plant of Swertia mileensis led to the isolation of two new triterpenoids, including a 28-nor-oleanane (1) and a 3,4-seco-3-nor-oleanane (2), together with 21 known triterpenoids (3-23). Their structures were elucidated by extensive spectroscopic analysis. Compounds 2 and 10 exhibited antiinflammatory activity by inhibiting the secretion of cytokines TNF-alpha and IL-6 in RAW264.7 cells induced by LPS with IC50 values ranging from 32.8 to 69.8 mu M. Compounds 1 and 17 showed cytotoxicity against HepG2 and MDA-MB-231 cells with inhibitory rates ranging from 30.34 % to 47.18 % at 10 mu M.
KeywordSwertia mileensis Gentianaceae Triterpenoids Anti-inflammatory activity Cytotoxicity
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
DOI10.1016/j.phytol.2023.03.001
Indexed BySCI
WOS IDWOS:000951787000001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/75426
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Yuan,Xin,Yan,Qin,Hu,Hong,et al. Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis[J]. PHYTOCHEMISTRY LETTERS,2023,55:1-5.
APA Yuan,Xin.,Yan,Qin.,Hu,Hong.,He,Xiao-Ping.,Wang,Li-Xia.,...&Li,Sheng-Hong.(2023).Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis.PHYTOCHEMISTRY LETTERS,55,1-5.
MLA Yuan,Xin,et al."Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis".PHYTOCHEMISTRY LETTERS 55(2023):1-5.
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