Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells

doi:10.1002/cbdv.202300218

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	Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells
	Dong,Lu; Li,Yanpeng; Qin,Fuying; Cheng,Yongxian
	2023
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1880
摘要	Four new germacrane-type sesquiterpenes commiphoranes M1-M4 (1-4) together with eighteen sesquiterpenes were isolated from the Resina Commiphora. The structures and relative configurations of new substances were determined by using spectroscopic methods. Biological activity investigation revealed that nine compounds including 7, 9, 14, 16, (+)-17, (-)-17, 18, 19, and 20 could induce the apoptosis of prostate cancer originated PC-3 cells, through classic apoptosis signaling pathway, even using flow cytometry showed that the compound (+)-17 caused apoptosis of PC-3 cells more than 40 %, suggesting their potential therapeutic application in the development of novel drugs against prostate cancer.
关键词	Resina Commiphora germacrane sesquiterpenes cell viability apoptosis PC-3 cells ANTIOXIDANT MYRRHA BERRYI MUKUL
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1002/cbdv.202300218
收录类别	SCI
WOS记录号	WOS:000970172700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75327
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Dong,Lu,Li,Yanpeng,Qin,Fuying,et al. Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells[J]. CHEMISTRY & BIODIVERSITY,2023.
APA	Dong,Lu,Li,Yanpeng,Qin,Fuying,&Cheng,Yongxian.(2023).Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells.CHEMISTRY & BIODIVERSITY.
MLA	Dong,Lu,et al."Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells".CHEMISTRY & BIODIVERSITY (2023).

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