Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis

doi:10.1021/acs.jafc.3c03784

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	Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis
	Chen,Yi-Chi; Liu,Yang-Yang; Chen,Liqiang; Tang,Dong-Mei; Zhao,Yunli; Luo,Xiao-Dong
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	71 期号:43 页码:16090-16101
摘要	Plumula Nelumbinis, the green embryo of a lotus seed, is widely consumed in China as a well-known food with medicinal effects. In this study, 14 alkaloids, including 4 new and 10 known alkaloids, were isolated from it, which were elucidated by comprehensive spectroscopic analysis, and were investigated for their antimelanogenic effects in vitro and in vivo. As a result, melanogenesis in alpha-MSH-stimulated B16F10 cells was reduced significantly by a new compound 4 and known compound 12 at a concentration of 0.5 mu g/mL, and the tyrosinase (TYR) activities were inhibited by 78.7 and 82.0% at 4 mu g/mL, prior to alpha-arbutin (41.3%). Additionally, compounds 4 and 12 also exhibited superior antimelanogenic effects compared to alpha-arbutin on a zebrafish assay model at equivalent concentrations. Mechanistically, our preliminary findings suggested that compounds 4 and 12 exerted antimelanogenesis effect probably by inhibiting key proteins involved in melanin production such as microphthalmia-associated transcription factor, TYR, TRP-1, and TRP-2. The findings highlight the potential use of Plumula Nelumbinis containing compounds 4 and 12 as functional foods for treating hyperpigmentation.
关键词	Plumula Nelumbinis melanin tyrosinase melanogenesis hyperpigmentation CHEMICAL-COMPOSITION DOWN-REGULATION LOTUS ANTIOXIDANT MELANOGENESIS FLAVONOIDS OXIDATION EMBRYO
DOI	10.1021/acs.jafc.3c03784
收录类别	SCI
WOS记录号	WOS:001092735700001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75301
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen,Yi-Chi,Liu,Yang-Yang,Chen,Liqiang,et al. Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(43):16090-16101.
APA	Chen,Yi-Chi,Liu,Yang-Yang,Chen,Liqiang,Tang,Dong-Mei,Zhao,Yunli,&Luo,Xiao-Dong.(2023).Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(43),16090-16101.
MLA	Chen,Yi-Chi,et al."Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.43(2023):16090-16101.

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