Identification and Characterization of Peptaibols as the Causing Agents of Pseudodiploospora longispora Infecting the Edible Mushroom Morchella

doi:10.1021/acs.jafc.3c05783

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	Identification and Characterization of Peptaibols as the Causing Agents of Pseudodiploospora longispora Infecting the Edible Mushroom Morchella
	Dong,Wang; Chen,Baosong; Zhang,Rui; Dai,Huanqin; Han,Junjie; Lu,Yongzhong; Zhao,Qi; Liu,Xingzhong; Liu,Hongwei; Sun,Jingzu
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	71 期号:47 页码:18385-18394
摘要	Pseudodiplo & ouml;spora longispora (previously known as Diplo & ouml;spora longispora) is a pathogenic fungus of Morchella mushrooms. The molecular mechanism underlying the infection of P. longispora in fruiting bodies remains unknown. In this study, three known peptaibols, alamethicin F-50, polysporin B, and septocylindrin B (1-3), and a new analogue, longisporin A (4), were detected and identified in the culture of P. longispora and the fruiting bodies of M. sextelata infected by P. longispora. The primary amino sequence of longisporin A is defined as Ac-Aib(1)-Pro(2)-Aib(3)-Ala(4)-Aib(5)-Aib(6)-Gln(7)-Aib(8)-Val(9)-Aib(10)-Glu(11)-Leu(12)-Aib(13)-Pro(14)-Val(15)-Aib(16)-Aib(17)-Gln(18)-Gln(19)-Phaol(20). The peptaibols 1-4 greatly suppressed the mycelial growth of M. sextelata. In addition, treatment with alamethicin F-50 produced damage on the cell wall and membrane of M. sextelata. Compounds 1-4 also exhibited inhibitory activities against human pathogens including Aspergillus fumigatus, Candida albicans, methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, and plant pathogen Verticillium dahlia. Herein, peptaibols are confirmed as virulence factors involved in the invasion of P. longispora on Morchella, providing insights into the interaction between pathogenic P. longispora and mushrooms.
关键词	Morchella sextelata Pseudodiploospora longispora mycoparasites peptaibols CATECHOLAMINE SECRETION PROLINE
DOI	10.1021/acs.jafc.3c05783
收录类别	SCI
WOS记录号	WOS:001096757700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75297
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Dong,Wang,Chen,Baosong,Zhang,Rui,et al. Identification and Characterization of Peptaibols as the Causing Agents of Pseudodiploospora longispora Infecting the Edible Mushroom Morchella[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(47):18385-18394.
APA	Dong,Wang.,Chen,Baosong.,Zhang,Rui.,Dai,Huanqin.,Han,Junjie.,...&Sun,Jingzu.(2023).Identification and Characterization of Peptaibols as the Causing Agents of Pseudodiploospora longispora Infecting the Edible Mushroom Morchella.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(47),18385-18394.
MLA	Dong,Wang,et al."Identification and Characterization of Peptaibols as the Causing Agents of Pseudodiploospora longispora Infecting the Edible Mushroom Morchella".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.47(2023):18385-18394.

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