O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50

doi:10.1021/acs.jnatprod.2c00892

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	O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50
	He,Xin; Peng,Guoqing; Luo,Jianying; Huang,Jian-Ping; Yang,Jing; Yan,Yijun; Gu,Yu-Cheng; Wang,Li; Huang,Sheng-Xiong
	2023
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	1520-6025
Abstract	Six new azoxy-aromatic compounds (o-alkylazoxymy-cins A-F, 1-6) and two new nitrogen-bearing phenylvaleric/ phenylheptanoic acid derivatives (o-alkylphemycins A and B, 7 and 8) were isolated from Streptomyces sp. Py50. Their structures were elucidated based on HRESIMS, NMR, UV spectroscopic analyses, and X-ray crystallographic data. O-Alkylazoxymycins A-F (1-6) are the first natural examples of azoxy compounds with the azoxy bond attached to the ortho-position of the phenylheptanoic acid or phenylvaleric acid moiety. Compounds 1, 5, and 6 were active against Epidermophyton floccosum with MIC50 values ranging from 10.1 to 51.2 mu M. A plausible biosynthetic pathway of 2 and 3 was proposed.
Keyword	ISOMERIZATION AZOXIDES
Subject Area	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1021/acs.jnatprod.2c00892
Indexed By	SCI
WOS ID	WOS:000918831800001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/75294
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	He,Xin,Peng,Guoqing,Luo,Jianying,et al. O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50[J]. JOURNAL OF NATURAL PRODUCTS,2023.
APA	He,Xin.,Peng,Guoqing.,Luo,Jianying.,Huang,Jian-Ping.,Yang,Jing.,...&Huang,Sheng-Xiong.(2023).O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50.JOURNAL OF NATURAL PRODUCTS.
MLA	He,Xin,et al."O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50".JOURNAL OF NATURAL PRODUCTS (2023).

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