Knowledge Management System of Kunming Institute of Botany,CAS
O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50 | |
He,Xin; Peng,Guoqing; Luo,Jianying![]() ![]() ![]() | |
2023 | |
Source Publication | JOURNAL OF NATURAL PRODUCTS
![]() |
ISSN | 1520-6025 |
Abstract | Six new azoxy-aromatic compounds (o-alkylazoxymy-cins A-F, 1-6) and two new nitrogen-bearing phenylvaleric/ phenylheptanoic acid derivatives (o-alkylphemycins A and B, 7 and 8) were isolated from Streptomyces sp. Py50. Their structures were elucidated based on HRESIMS, NMR, UV spectroscopic analyses, and X-ray crystallographic data. O-Alkylazoxymycins A-F (1-6) are the first natural examples of azoxy compounds with the azoxy bond attached to the ortho-position of the phenylheptanoic acid or phenylvaleric acid moiety. Compounds 1, 5, and 6 were active against Epidermophyton floccosum with MIC50 values ranging from 10.1 to 51.2 mu M. A plausible biosynthetic pathway of 2 and 3 was proposed. |
Keyword | ISOMERIZATION AZOXIDES |
Subject Area | Plant Sciences ; Pharmacology & Pharmacy |
DOI | 10.1021/acs.jnatprod.2c00892 |
Indexed By | SCI |
WOS ID | WOS:000918831800001 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/75294 |
Collection | 中国科学院昆明植物研究所 |
Recommended Citation GB/T 7714 | He,Xin,Peng,Guoqing,Luo,Jianying,et al. O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50[J]. JOURNAL OF NATURAL PRODUCTS,2023. |
APA | He,Xin.,Peng,Guoqing.,Luo,Jianying.,Huang,Jian-Ping.,Yang,Jing.,...&Huang,Sheng-Xiong.(2023).O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50.JOURNAL OF NATURAL PRODUCTS. |
MLA | He,Xin,et al."O-Alkylazoxymycins A-F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50".JOURNAL OF NATURAL PRODUCTS (2023). |
Files in This Item: | Download All | |||||
File Name/Size | DocType | Version | Access | License | ||
10.1021_acs.jnatprod(1709KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment