Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis

doi:10.1021/acs.jnatprod.3c00493

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	Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis
	Jin,Qiong; Qin,Xu-Jie; Sun,Wen-Jie; Ding,Xiao; Zhao,Yun; Wang,Chang-Bin; Tao,Xing-Yu; Luo,Xiao-Dong
	2023
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	1520-6025
Volume	86 Issue:9 Pages:2193-2205
Abstract	Sixteen new quinolizidine alkaloids (QAs), named ormosianinesA-P(1-16), and 18 known congeners (17-34) were isolated from the stems andleaves of Ormosia yunnanensis. The structures wereelucidated based on spectroscopic analyses and electron circular dichroism(ECD) calculations. Structurally, ormosianines A (1)and B (2) are the first examples of cytisine and Ormosia-type alkaloids with the cleavage of the piperidinering. Results of the acetylcholinesterase (AChE) inhibitory assayrevealed that the pentacycline Ormosia-type QAs,including 1, 16, 24, and 27-29, are good AChE inhibitors. OrmosianineA (1) exhibited more potent AChE inhibitory activitywith an IC50 value of 1.55 & mu;M. Molecular dockingrevealed that 1 might bind to the protein 1DX4, formingtwo hydrogen bonds with residues SER-238 and HIS-480.
Keyword	ACETYLCHOLINESTERASE SEEDS PLANTS
DOI	10.1021/acs.jnatprod.3c00493
Indexed By	SCI
WOS ID	WOS:001050142300001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/75293
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Jin,Qiong,Qin,Xu-Jie,Sun,Wen-Jie,et al. Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(9):2193-2205.
APA	Jin,Qiong.,Qin,Xu-Jie.,Sun,Wen-Jie.,Ding,Xiao.,Zhao,Yun.,...&Luo,Xiao-Dong.(2023).Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis.JOURNAL OF NATURAL PRODUCTS,86(9),2193-2205.
MLA	Jin,Qiong,et al."Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis".JOURNAL OF NATURAL PRODUCTS 86.9(2023):2193-2205.

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