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Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis
Jin,Qiong; Qin,Xu-Jie; Sun,Wen-Jie; Ding,Xiao; Zhao,Yun; Wang,Chang-Bin; Tao,Xing-Yu; Luo,Xiao-Dong
2023
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN1520-6025
Volume86Issue:9Pages:2193-2205
AbstractSixteen new quinolizidine alkaloids (QAs), named ormosianinesA-P(1-16), and 18 known congeners (17-34) were isolated from the stems andleaves of Ormosia yunnanensis. The structures wereelucidated based on spectroscopic analyses and electron circular dichroism(ECD) calculations. Structurally, ormosianines A (1)and B (2) are the first examples of cytisine and Ormosia-type alkaloids with the cleavage of the piperidinering. Results of the acetylcholinesterase (AChE) inhibitory assayrevealed that the pentacycline Ormosia-type QAs,including 1, 16, 24, and 27-29, are good AChE inhibitors. OrmosianineA (1) exhibited more potent AChE inhibitory activitywith an IC50 value of 1.55 & mu;M. Molecular dockingrevealed that 1 might bind to the protein 1DX4, formingtwo hydrogen bonds with residues SER-238 and HIS-480.
KeywordACETYLCHOLINESTERASE SEEDS PLANTS
DOI10.1021/acs.jnatprod.3c00493
Indexed BySCI
WOS IDWOS:001050142300001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/75293
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Jin,Qiong,Qin,Xu-Jie,Sun,Wen-Jie,et al. Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(9):2193-2205.
APA Jin,Qiong.,Qin,Xu-Jie.,Sun,Wen-Jie.,Ding,Xiao.,Zhao,Yun.,...&Luo,Xiao-Dong.(2023).Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis.JOURNAL OF NATURAL PRODUCTS,86(9),2193-2205.
MLA Jin,Qiong,et al."Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis".JOURNAL OF NATURAL PRODUCTS 86.9(2023):2193-2205.
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