Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis

doi:10.1021/acs.jnatprod.3c00498

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	Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis
	Ye,Yan-Song; Duan,Yao-Tao; Zhou,Zhuo; Thepkaysone,Khamphanh; Douangdeuane,Bounleuane; Xu,Gang
	2023
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	1520-6025
卷号	86 期号:9 页码:2206-2215
摘要	Thirty-five diverse polyphenols, belonging to seven structure classes, were isolated from Garcinia gracilis, a medicinal and edible plant sampled from Laos. The structures of nine new compounds, gargarcilones A-I (1-3, 5-7, 10, 12, and 17), were established using spectroscopic, X-ray diffraction, and experimental and calculated ECD methods. Additionally, we revised the stereochemical assignment of cochinchinoxanthone and cochinchinoxanthone C. The compounds were evaluated for antiproliferative activity against five human tumor cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, and SW480). Compounds 1-4, 7, and 8 exhibited cytotoxic activity with IC50 values of 0.5-8.9 mu M. Compound 3 significantly induced apoptosis in SMMC-7721 cells.
关键词	CAGED XANTHONES CONSTITUENTS INHIBITORS BENZOPHENONES DERIVATIVES BIPHENYL TWIGS
DOI	10.1021/acs.jnatprod.3c00498
收录类别	SCI
WOS记录号	WOS:001060968500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75292
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Ye,Yan-Song,Duan,Yao-Tao,Zhou,Zhuo,et al. Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(9):2206-2215.
APA	Ye,Yan-Song,Duan,Yao-Tao,Zhou,Zhuo,Thepkaysone,Khamphanh,Douangdeuane,Bounleuane,&Xu,Gang.(2023).Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis.JOURNAL OF NATURAL PRODUCTS,86(9),2206-2215.
MLA	Ye,Yan-Song,et al."Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis".JOURNAL OF NATURAL PRODUCTS 86.9(2023):2206-2215.

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