Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714

doi:10.1021/acs.orglett.3c00478

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	Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714
	He,Xin; Ren,Jinqiu; Wang,Li; Luo,Jianying; Yang,Jing; Gu,Yu-Cheng; Yan,Yijun; Huang,Sheng-Xiong
	2023
发表期刊	ORGANIC LETTERS
ISSN	1523-7052
卷号	25 期号:10 页码:1760-1764
摘要	Quinolizidomycins A (1) and B (2), two unprecedented quinolizidine alkaloids featuring a tricyclic 6/6/5 ring system, were isolated from Streptomyces sp. KIB-1714. Their structures were assigned by detailed spectroscopic data analyses and X-ray diffraction. Stable isotope labeling experiments suggested that compounds 1 and 2 are derived from lysine, ribose 5-phosphate, and acetate units, which indicates an unprecedented manner of assembly of the quinolizidine (1-azabicyclo[4.4.0]decane) scaffold in quinolizidomycin biosynthesis. Quinolizidomycin A (1) was active in an acetylcholinesterase inhibitory assay.
学科领域	Chemistry
DOI	10.1021/acs.orglett.3c00478
收录类别	SCI
WOS记录号	WOS:000957722700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75288
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	He,Xin,Ren,Jinqiu,Wang,Li,et al. Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714[J]. ORGANIC LETTERS,2023,25(10):1760-1764.
APA	He,Xin.,Ren,Jinqiu.,Wang,Li.,Luo,Jianying.,Yang,Jing.,...&Huang,Sheng-Xiong.(2023).Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714.ORGANIC LETTERS,25(10),1760-1764.
MLA	He,Xin,et al."Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714".ORGANIC LETTERS 25.10(2023):1760-1764.

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