Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla

doi:10.1021/acs.orglett.3c01342

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	Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla
	Zhou,Hao-Feng; Li,Wen-Yan; Wu,Qi; Ren,Jian; Peng,Li-Yan; Li,Xiao-Nian; Zhao,Qin-Shi
	2023
发表期刊	ORGANIC LETTERS
ISSN	1523-7052
卷号	25 期号:24 页码:4434-4438
摘要	Spirophyllines A-D (1-4), four new spirooxindole alkaloids all characterized bythe spiro[pyrrolidin-3,3 '-oxindole]core and a rare isoxazolidine ring, were isolated from Uncariarhynchophylla. Their structures were determined by spectroscopicmethods and confirmed by X-ray crystallography. Based on the biomimeticsemisynthesis strategy, compounds 1-8 were synthesized in three steps via the key reactions of 1,3-dipolarcycloaddition and Krapcho decarboxylation from corynoxeine. Interestingly,compound 3 showed moderate inhibitory activity againstthe K(v)1.5 potassium channel (IC50 = 9.1 mu M).
关键词	ATRIAL INHIBITORS CHANNELS
学科领域	Chemistry
DOI	10.1021/acs.orglett.3c01342
收录类别	SCI
WOS记录号	WOS:001004393600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75285
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhou,Hao-Feng,Li,Wen-Yan,Wu,Qi,et al. Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla[J]. ORGANIC LETTERS,2023,25(24):4434-4438.
APA	Zhou,Hao-Feng.,Li,Wen-Yan.,Wu,Qi.,Ren,Jian.,Peng,Li-Yan.,...&Zhao,Qin-Shi.(2023).Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla.ORGANIC LETTERS,25(24),4434-4438.
MLA	Zhou,Hao-Feng,et al."Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla".ORGANIC LETTERS 25.24(2023):4434-4438.

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