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| Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla | |
| Zhou,Hao-Feng; Li,Wen-Yan; Wu,Qi; Ren,Jian; Peng,Li-Yan; Li,Xiao-Nian; Zhao,Qin-Shi | |
| 2023 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7052 |
| Volume | 25Issue:24Pages:4434-4438 |
| Abstract | Spirophyllines A-D (1-4), four new spirooxindole alkaloids all characterized bythe spiro[pyrrolidin-3,3 '-oxindole]core and a rare isoxazolidine ring, were isolated from Uncariarhynchophylla. Their structures were determined by spectroscopicmethods and confirmed by X-ray crystallography. Based on the biomimeticsemisynthesis strategy, compounds 1-8 were synthesized in three steps via the key reactions of 1,3-dipolarcycloaddition and Krapcho decarboxylation from corynoxeine. Interestingly,compound 3 showed moderate inhibitory activity againstthe K(v)1.5 potassium channel (IC50 = 9.1 mu M). |
| Keyword | ATRIAL INHIBITORS CHANNELS |
| Subject Area | Chemistry |
| DOI | 10.1021/acs.orglett.3c01342 |
| Indexed By | SCI |
| WOS ID | WOS:001004393600001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/75285 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Zhou,Hao-Feng,Li,Wen-Yan,Wu,Qi,et al. Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla[J]. ORGANIC LETTERS,2023,25(24):4434-4438. |
| APA | Zhou,Hao-Feng.,Li,Wen-Yan.,Wu,Qi.,Ren,Jian.,Peng,Li-Yan.,...&Zhao,Qin-Shi.(2023).Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla.ORGANIC LETTERS,25(24),4434-4438. |
| MLA | Zhou,Hao-Feng,et al."Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla".ORGANIC LETTERS 25.24(2023):4434-4438. |
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| 10.1021_acs.orglett.（2106KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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