Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation

doi:10.1021/acs.orglett.3c01659

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	Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation
	Li,Lei; Yang,Hua-Fei; Ding,Qian-Hui; Wei,Kun; Yang,Yu-Rong
	2023
发表期刊	ORGANIC LETTERS
ISSN	1523-7052
摘要	Metallaphotoredox-enableddeoxygenative arylation of alcohols isa recently developed robust synthetic strategy for sp(2)-sp(3) coupling by MacMillan. Inspired by this method, we reportherein its first utilization in natural product total synthesis throughrealizing the coupling of 4-bromo-quinoline or 4-bromo-6-methoxyquinolinewith quincorine or quincoridine, respectively. The alcohols were denovo synthesized in racemic form by a key step of the intramolecularDiels-Alder reaction or in an enantioselective manner by Ir/aminedual-catalyzed allylation. All members of the cinchona alkaloids couldbe prepared efficiently.
关键词	ASYMMETRIC TOTAL SYNTHESES ALPHA-ALLYLATION FORMAL SYNTHESIS QUININE
学科领域	Chemistry
DOI	10.1021/acs.orglett.3c01659
收录类别	SCI
WOS记录号	WOS:001006586100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75284
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li,Lei,Yang,Hua-Fei,Ding,Qian-Hui,et al. Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation[J]. ORGANIC LETTERS,2023.
APA	Li,Lei,Yang,Hua-Fei,Ding,Qian-Hui,Wei,Kun,&Yang,Yu-Rong.(2023).Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation.ORGANIC LETTERS.
MLA	Li,Lei,et al."Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation".ORGANIC LETTERS (2023).

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