Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity

doi:10.3390/ph16020193

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	Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity
	Zhang,Xian; Fan,Yinzhong; Ye,Ke; Pan,Xiaoyan; Ma,Xujun; Ai,Honglian; Shi,Baobao; Liu,Jikai
	2023
发表期刊	PHARMACEUTICALS
ISSN	1424-8247
卷号	16 期号:2 页码:193
摘要	Six previously undescribed cytochalasins, Curtachalasins X1-X6 (1-6), together with six known compounds (7-12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum. The structures were elucidated by the interpretation of HRESIMS, UV, and NMR data. The absolute configurations of Curtachalasins X1-X6 were determined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. In bioassays, Curtachalasin X1 (1) and X5 (5) showed cytotoxic activity against the MCF-7 cell line with IC50 values of 2.03 mu M and 0.85 mu M, respectively.
关键词	endophyte fungus Xylaria curta cytochalasins isolation and structure elucidation cytotoxicity A-D METABOLITES
学科领域	Pharmacology & Pharmacy
DOI	10.3390/ph16020193
WOS记录号	WOS:000941690100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75043
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang,Xian,Fan,Yinzhong,Ye,Ke,et al. Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity[J]. PHARMACEUTICALS,2023,16(2):193.
APA	Zhang,Xian.,Fan,Yinzhong.,Ye,Ke.,Pan,Xiaoyan.,Ma,Xujun.,...&Liu,Jikai.(2023).Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity.PHARMACEUTICALS,16(2),193.
MLA	Zhang,Xian,et al."Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity".PHARMACEUTICALS 16.2(2023):193.

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