New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition

doi:10.3390/molecules28124590

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	New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
	Meng,Qianqian; Tong,Shunyao; Zhao,Yuqing; Peng,Xingrong; Li,Zhenghui; Feng,Tao; Liu,Jikai
	2023
发表期刊	MOLECULES
ISSN	1420-3049
卷号	28 期号:12 页码:4590
摘要	The Paeonia suffruticosa, known as 'Feng Dan', has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A-E (1-5), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds 2, 4, and 5 showed cytotoxicity against three human cancer cell lines, with IC50 values ranging from 6.7 to 25.1 & mu;M. Compounds 1 and 2 showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of P. suffruticosa are reported for the first time in this paper.
关键词	Paeonia suffruticosa benzofuranones cytotoxicity NO production inhibition MOUTAN CORTEX SESQUITERPENE CONSTITUENTS
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/molecules28124590
WOS记录号	WOS:001017545500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75038
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Meng,Qianqian,Tong,Shunyao,Zhao,Yuqing,et al. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition[J]. MOLECULES,2023,28(12):4590.
APA	Meng,Qianqian.,Tong,Shunyao.,Zhao,Yuqing.,Peng,Xingrong.,Li,Zhenghui.,...&Liu,Jikai.(2023).New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition.MOLECULES,28(12),4590.
MLA	Meng,Qianqian,et al."New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition".MOLECULES 28.12(2023):4590.

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