Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima

doi:10.3390/molecules28062705

KIB OpenIR

	Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima
	Meng,Qian-Qian; Tong,Shun-Yao; Peng,Xing-Rong; Zhao,Yu-Qing; Li,Zheng-Hui; Chen,He-Ping; Liu,Ji-Kai
	2023
发表期刊	MOLECULES
ISSN	1420-3049
卷号	28 期号:6 页码:2705
摘要	The ethnobotanical plant Marsdenia tenacissima has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I (1-9), were isolated from cultivated dried stems of the medicinal plant Marsdenia tenacissima in this study. The structures were analyzed by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and IR spectroscopic analysis. The absolute configurations of the sugar moieties were identified by comparing the R-f values and specific optical rotations with those of the commercially available standard samples and the data reported in the literature. Marsdeosides A (1) featured an unusual 8,14-seco-pregnane skeleton. Compounds 1, 8, and 9 showed activity against nitric oxide production in lipopolysaccharide-activated macrophage RAW264.7, with IC50 values of 37.5, 38.8, and 42.8 mu M (L-NMMA was used as a positive control, IC50 39.3 mu M), respectively. This study puts the knowledge of the chemical profile of the botanical plant M. tenacissima one step forward and, thereby, promotes the sustainable utilization of the resources of traditional folk medicinal plants.
关键词	Marsdenia tenacissima (Roxb ) moon asclepiadaceae pregnane glycosides structural elucidation nitric oxide production inhibition STEMS
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/molecules28062705
WOS记录号	WOS:000958792300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75037
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Meng,Qian-Qian,Tong,Shun-Yao,Peng,Xing-Rong,et al. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima[J]. MOLECULES,2023,28(6):2705.
APA	Meng,Qian-Qian.,Tong,Shun-Yao.,Peng,Xing-Rong.,Zhao,Yu-Qing.,Li,Zheng-Hui.,...&Liu,Ji-Kai.(2023).Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima.MOLECULES,28(6),2705.
MLA	Meng,Qian-Qian,et al."Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima".MOLECULES 28.6(2023):2705.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.3390_molecules280（792KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载