KIB OpenIR
Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima
Meng,Qian-Qian; Tong,Shun-Yao; Peng,Xing-Rong; Zhao,Yu-Qing; Li,Zheng-Hui; Chen,He-Ping; Liu,Ji-Kai
2023
Source PublicationMOLECULES
ISSN1420-3049
Volume28Issue:6Pages:2705
AbstractThe ethnobotanical plant Marsdenia tenacissima has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I (1-9), were isolated from cultivated dried stems of the medicinal plant Marsdenia tenacissima in this study. The structures were analyzed by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and IR spectroscopic analysis. The absolute configurations of the sugar moieties were identified by comparing the R-f values and specific optical rotations with those of the commercially available standard samples and the data reported in the literature. Marsdeosides A (1) featured an unusual 8,14-seco-pregnane skeleton. Compounds 1, 8, and 9 showed activity against nitric oxide production in lipopolysaccharide-activated macrophage RAW264.7, with IC50 values of 37.5, 38.8, and 42.8 mu M (L-NMMA was used as a positive control, IC50 39.3 mu M), respectively. This study puts the knowledge of the chemical profile of the botanical plant M. tenacissima one step forward and, thereby, promotes the sustainable utilization of the resources of traditional folk medicinal plants.
KeywordMarsdenia tenacissima (Roxb ) moon asclepiadaceae pregnane glycosides structural elucidation nitric oxide production inhibition STEMS
Subject AreaBiochemistry & Molecular Biology ; Chemistry
DOI10.3390/molecules28062705
WOS IDWOS:000958792300001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/75037
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Meng,Qian-Qian,Tong,Shun-Yao,Peng,Xing-Rong,et al. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima[J]. MOLECULES,2023,28(6):2705.
APA Meng,Qian-Qian.,Tong,Shun-Yao.,Peng,Xing-Rong.,Zhao,Yu-Qing.,Li,Zheng-Hui.,...&Liu,Ji-Kai.(2023).Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima.MOLECULES,28(6),2705.
MLA Meng,Qian-Qian,et al."Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima".MOLECULES 28.6(2023):2705.
Files in This Item: Download All
File Name/Size DocType Version Access License
10.3390_molecules280(792KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Meng,Qian-Qian]'s Articles
[Tong,Shun-Yao]'s Articles
[Peng,Xing-Rong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Meng,Qian-Qian]'s Articles
[Tong,Shun-Yao]'s Articles
[Peng,Xing-Rong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Meng,Qian-Qian]'s Articles
[Tong,Shun-Yao]'s Articles
[Peng,Xing-Rong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.3390_molecules28062705.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.