Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima

doi:10.3390/molecules28062705

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	Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima
	Meng,Qian-Qian; Tong,Shun-Yao; Peng,Xing-Rong; Zhao,Yu-Qing; Li,Zheng-Hui; Chen,He-Ping; Liu,Ji-Kai
	2023
Source Publication	MOLECULES
ISSN	1420-3049
Volume	28 Issue:6 Pages:2705
Abstract	The ethnobotanical plant Marsdenia tenacissima has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I (1-9), were isolated from cultivated dried stems of the medicinal plant Marsdenia tenacissima in this study. The structures were analyzed by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and IR spectroscopic analysis. The absolute configurations of the sugar moieties were identified by comparing the R-f values and specific optical rotations with those of the commercially available standard samples and the data reported in the literature. Marsdeosides A (1) featured an unusual 8,14-seco-pregnane skeleton. Compounds 1, 8, and 9 showed activity against nitric oxide production in lipopolysaccharide-activated macrophage RAW264.7, with IC50 values of 37.5, 38.8, and 42.8 mu M (L-NMMA was used as a positive control, IC50 39.3 mu M), respectively. This study puts the knowledge of the chemical profile of the botanical plant M. tenacissima one step forward and, thereby, promotes the sustainable utilization of the resources of traditional folk medicinal plants.
Keyword	Marsdenia tenacissima (Roxb ) moon asclepiadaceae pregnane glycosides structural elucidation nitric oxide production inhibition STEMS
Subject Area	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/molecules28062705
WOS ID	WOS:000958792300001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/75037
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Meng,Qian-Qian,Tong,Shun-Yao,Peng,Xing-Rong,et al. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima[J]. MOLECULES,2023,28(6):2705.
APA	Meng,Qian-Qian.,Tong,Shun-Yao.,Peng,Xing-Rong.,Zhao,Yu-Qing.,Li,Zheng-Hui.,...&Liu,Ji-Kai.(2023).Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima.MOLECULES,28(6),2705.
MLA	Meng,Qian-Qian,et al."Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima".MOLECULES 28.6(2023):2705.

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