Insights from the Endophytic Fungi in Amphisphaeria (Sordariomycetes): A. orixae sp. nov. from Orixa japonica and Its Secondary Metabolites

doi:10.3390/microorganisms11051268

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	Insights from the Endophytic Fungi in Amphisphaeria (Sordariomycetes): A. orixae sp. nov. from Orixa japonica and Its Secondary Metabolites
	Wang,Xiaojie; Wanasinghe,Dhanushka N.; Zhang,Jingyi; Ma,Jian; Zhou,Peifeng; Zhang,Lijuan; Lu,Yongzhong; Zhang,Zhen
	2023
发表期刊	MICROORGANISMS
ISSN	2076-2607
卷号	11 期号:5 页码:1268
摘要	Endophytic fungi are a remarkably diverse group of microorganisms that have imperceptible associations with their hosts for at least a part of their life cycle. The enormous biological diversity and the capability of producing bioactive secondary metabolites such as alkaloids, terpenoids, and polyketides have attracted the attention of different scientific communities, resulting in numerous investigations on these fungal endophytes. During our surveys of plant-root-based fungi in the mountain areas of Qingzhen, Guizhou Province, several isolates of endophytic fungi were identified. In this study, a novel endophytic fungus was discovered in the roots of a medicinal plant (Orixa japonica) in Southern China and introduced as a new species (Amphisphaeria orixae) based on morphological evidence and molecular phylogenetic analysis (combined ITS and LSU sequence data). To the best of our knowledge, A. orixae is the first reported endophyte as well as the first hyphomycetous asexual morph in Amphisphaeria. A new isocoumarin, (R)-4,6,8-trihydroxy-5-methylisochroman-1-one (1), and 12 known compounds (2-13) were isolated from the rice fermentation products of this fungus. Using 1D- and 2D-NMR, mass spectrometry, and ECD studies, their structures were identified. The antitumor activity of these compounds was tested. Unfortunately, none of the compounds tested showed significant antitumor activity.
关键词	Amphisphaeriales fungal taxonomy hyphomycetes isocoumarin phylogeny SP.-NOV. ALKALOIDS CONSTITUENTS ALIGNMENT CHOICE
学科领域	Microbiology
DOI	10.3390/microorganisms11051268
WOS记录号	WOS:000996681400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75034
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Xiaojie,Wanasinghe,Dhanushka N.,Zhang,Jingyi,et al. Insights from the Endophytic Fungi in Amphisphaeria (Sordariomycetes): A. orixae sp. nov. from Orixa japonica and Its Secondary Metabolites[J]. MICROORGANISMS,2023,11(5):1268.
APA	Wang,Xiaojie.,Wanasinghe,Dhanushka N..,Zhang,Jingyi.,Ma,Jian.,Zhou,Peifeng.,...&Zhang,Zhen.(2023).Insights from the Endophytic Fungi in Amphisphaeria (Sordariomycetes): A. orixae sp. nov. from Orixa japonica and Its Secondary Metabolites.MICROORGANISMS,11(5),1268.
MLA	Wang,Xiaojie,et al."Insights from the Endophytic Fungi in Amphisphaeria (Sordariomycetes): A. orixae sp. nov. from Orixa japonica and Its Secondary Metabolites".MICROORGANISMS 11.5(2023):1268.

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