New Lupanes from Alstonia scholaris Reducing Uric Acid Level

doi:10.1055/a-2186-3260

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	New Lupanes from Alstonia scholaris Reducing Uric Acid Level
	Hu, Bin-Yuan; Zhao, Yun-Li; Xu, Yuan; Wang, Xiao-Na; Luo, Xiao-Dong
	2024
发表期刊	PLANTA MEDICA
卷号	90 期号:1 页码:38-46
摘要	Twelve lupanes including three new compounds named alstoscholarilups A-C ( 1 - 3 ) were isolated from the leaves of Alstonia scholaris . Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28- nor and 3 with a 29- nor -lupane skeleton supported the phytochemical diversity and novelty of the plant. Pharmacologically, compounds 4, 7 , and 10 reduced the serum uric acid (UA) levels of mice significantly.
关键词	Alstonia scholaris Apocynaceae reducing UA levels lupanes PENTACYCLIC TRITERPENES INDOLE ALKALOIDS LEAVES
学科领域	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
DOI	10.1055/a-2186-3260
WOS记录号	WOS:001085556700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74884
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Hu, Bin-Yuan,Zhao, Yun-Li,Xu, Yuan,et al. New Lupanes from Alstonia scholaris Reducing Uric Acid Level[J]. PLANTA MEDICA,2024,90(1):38-46.
APA	Hu, Bin-Yuan,Zhao, Yun-Li,Xu, Yuan,Wang, Xiao-Na,&Luo, Xiao-Dong.(2024).New Lupanes from Alstonia scholaris Reducing Uric Acid Level.PLANTA MEDICA,90(1),38-46.
MLA	Hu, Bin-Yuan,et al."New Lupanes from Alstonia scholaris Reducing Uric Acid Level".PLANTA MEDICA 90.1(2024):38-46.

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