Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces

doi:10.1038/s43247-023-00790-w

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	Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces
	Wang,Hang; Qi,Jin-Feng; Qin,Rong; Ding,Kai; Graham,David W.; Zhu,Yong-Guan
	2023
发表期刊	COMMUNICATIONS EARTH & ENVIRONMENT
ISSN	2662-4435
卷号	4 期号:1 页码:123
摘要	Intensively reared animals have higher levels of antibiotic resistance in feces than those living in small-scale and free-range ways, according to genotype and phenotype profiles of antibiotic resistance in animal feces from eight Chinese farms. Animal feces from livestock farming can be a major source of antibiotic resistance to the environment, but a clear gap exists on how the resistance reservoir in feces alters as farming activities intensify. Here, we sampled feces from eight Chinese farms, where yak, sheep, pig, and horse were reared under free-range to intensive conditions, and determined fecal resistance using both genotype and phenotype approaches. Animals reared intensively exhibited increased diversity of antibiotic resistance genes and greater resistance phenotypes in feces, which were cross-correlated. Furthermore, at the metagenome contig level, antibiotic resistance genes were co-located with mobile genetic elements at a higher frequency (27.38%) as farming intensified, with associated resistance phenotypes being less coupled with bacterial phylogeny. Intensified farming also expanded the multidrug resistance preferentially carried on pathogens in fecal microbiomes. Overall, farming intensification can increase antibiotic resistance genotypes and phenotypes in domestic animal feces, with implications for environmental health.
关键词	VETERINARY ANTIBIOTICS SWINE SOIL MANURE GENES RESISTOMES ABUNDANCE BACTERIA CATTLE FEED
学科领域	Environmental Sciences & Ecology ; Geology ; Meteorology & Atmospheric Sciences
DOI	10.1038/s43247-023-00790-w
WOS记录号	WOS:000972248500003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74879
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Hang,Qi,Jin-Feng,Qin,Rong,et al. Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces[J]. COMMUNICATIONS EARTH & ENVIRONMENT,2023,4(1):123.
APA	Wang,Hang,Qi,Jin-Feng,Qin,Rong,Ding,Kai,Graham,David W.,&Zhu,Yong-Guan.(2023).Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces.COMMUNICATIONS EARTH & ENVIRONMENT,4(1),123.
MLA	Wang,Hang,et al."Intensified livestock farming increases antibiotic resistance genotypes and phenotypes in animal feces".COMMUNICATIONS EARTH & ENVIRONMENT 4.1(2023):123.

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