Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia

doi:10.1038/s41467-023-40401-y

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	Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia
	Hu,Jiadong; Qiu,Shi; Wang,Feiyan; Li,Qing; Xiang,Chun-Lei; Di,Peng; Wu,Ziding; Jiang,Rui; Li,Jinxing; Zeng,Zhen; Wang,Jing; Wang,Xingxing; Zhang,Yuchen; Fang,Shiyuan; Qiao,Yuqi; Ding,Jie; Jiang,Yun; Xu,Zhichao; Chen,Junfeng; Chen,Wansheng
	2023
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	14 期号:1 页码:4696
摘要	The genus Salvia L. (Lamiaceae) comprises myriad distinct medicinal herbs, with terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs), such as tanshinones and carnosic acids, are specific to Salvia and exhibit taxonomic chemical diversity among lineages. To elucidate how ATD chemical diversity evolved, we carried out large-scale metabolic and phylogenetic analyses of 71 Salvia species, combined with enzyme function, ancestral sequence and chemical trait reconstruction, and comparative genomics experiments. This integrated approach showed that the lineage-wide ATD diversities in Salvia were induced by differences in the oxidation of the terpenoid skeleton at C-20, which was caused by the functional divergence of the cytochrome P450 subfamily CYP76AK. These findings present a unique pattern of chemical diversity in plants that was shaped by the loss of enzyme activity and associated catalytic pathways. Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage.
关键词	CARNOSIC ACID PHYLOGENETIC ANALYSIS ARABIDOPSIS-THALIANA GENOME DUPLICATIONS STAMINAL EVOLUTION LAMIACEAE BIOSYNTHESIS TANSHINONES TOOL
DOI	10.1038/s41467-023-40401-y
WOS记录号	WOS:001042606700016
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74868
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Hu,Jiadong,Qiu,Shi,Wang,Feiyan,et al. Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia[J]. NATURE COMMUNICATIONS,2023,14(1):4696.
APA	Hu,Jiadong.,Qiu,Shi.,Wang,Feiyan.,Li,Qing.,Xiang,Chun-Lei.,...&Chen,Wansheng.(2023).Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia.NATURE COMMUNICATIONS,14(1),4696.
MLA	Hu,Jiadong,et al."Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia".NATURE COMMUNICATIONS 14.1(2023):4696.

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