A natural biological adhesive from snail mucus for wound repair

doi:10.1038/s41467-023-35907-4

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	A natural biological adhesive from snail mucus for wound repair
	Deng, Tuo; Gao, Dongxiu; Song, Xuemei; Zhou, Zhipeng; Zhou, Lixiao; Tao, Maixian; Jiang, Zexiu; Yang, Lian; Luo, Lan; Zhou, Ankun; Hu, Lin; Qin, Hongbo; Wu, Mingyi
	2023
发表期刊	NATURE COMMUNICATIONS
卷号	14 期号:1 页码:396
摘要	The discovery of natural adhesion phenomena andmechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.
关键词	FOOT GLYCOSAMINOGLYCANS OPPORTUNITIES POLARIZATION CHEMISTRY PROTEINS HELIX CARE
学科领域	Science & Technology - Other Topics
DOI	10.1038/s41467-023-35907-4
WOS记录号	WOS:001170148000004
引用统计	被引频次：55[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74864
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Deng, Tuo,Gao, Dongxiu,Song, Xuemei,et al. A natural biological adhesive from snail mucus for wound repair[J]. NATURE COMMUNICATIONS,2023,14(1):396.
APA	Deng, Tuo.,Gao, Dongxiu.,Song, Xuemei.,Zhou, Zhipeng.,Zhou, Lixiao.,...&Wu, Mingyi.(2023).A natural biological adhesive from snail mucus for wound repair.NATURE COMMUNICATIONS,14(1),396.
MLA	Deng, Tuo,et al."A natural biological adhesive from snail mucus for wound repair".NATURE COMMUNICATIONS 14.1(2023):396.

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