Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities

doi:10.1007/s12272-023-01466-x

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	Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities
	Shang,Chong; Ma,Yun-Bao; Wang,Yuan; He,Xiao-Feng; Li,Tian-Ze; Chen,Ji-Jun
	2023
发表期刊	ARCHIVES OF PHARMACAL RESEARCH
ISSN	1976-3786
卷号	46 期号:9-10 页码:782-794
摘要	Artemongolins A-K (1-11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A-K (1-11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluation against three human hepatoma cell lines demonstrated that the most active compounds 5 and 6 displayed inhibitory activity with IC50 values of 88.6 and 57.0 (HepG2), 59.1 and 26.4 (Huh7), and 67.5 and 32.5 (SK-Hep-1) mu M, respectively.
关键词	Artemisia mongolica Artemongolins A-K Sesquiterpenoid dimers Antihepatoma activity HEPATOCELLULAR-CARCINOMA LACTONE ARGYI
DOI	10.1007/s12272-023-01466-x
WOS记录号	WOS:001075038900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74829
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Shang,Chong,Ma,Yun-Bao,Wang,Yuan,et al. Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities[J]. ARCHIVES OF PHARMACAL RESEARCH,2023,46(9-10):782-794.
APA	Shang,Chong,Ma,Yun-Bao,Wang,Yuan,He,Xiao-Feng,Li,Tian-Ze,&Chen,Ji-Jun.(2023).Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities.ARCHIVES OF PHARMACAL RESEARCH,46(9-10),782-794.
MLA	Shang,Chong,et al."Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities".ARCHIVES OF PHARMACAL RESEARCH 46.9-10(2023):782-794.

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