Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis

doi:10.1007/s11427-022-2265-6

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	Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis
	Yang,Xiaoyu; Chen,Yonghong; Zhang,Longlong; He,Jiangbo; Wu,Qunfu; Li,Shuhong; Wang,Donglou; Gou,Jianghui; Wu,Zhuang; Zhang,Keqin; Li,Shenghong; Niu,Xuemei
	2023
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1869-1889
摘要	The discovery of biological activities of natural products plays a vital part in drug development. The mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic. A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid mass. Deficiency in 1 caused melanin loss and accumulated extra lipid mass, unexpectedly leading to seriously damaged mitochondria diagnostic for ferroptosis. Further analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid peroxidation. We also found that melanin in mice lowered lipid level but enhanced animal resistance to cold stress. Treatment with melanin precursors significantly increased mouse cell survival rate under cold stress. Our results unveiled a metabolite-lipid-ferroptosis-cold relationship, which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold stress. These findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents.
关键词	melanin precursor lipid ferroptosis temperature change anti-cold COLD STRESS PIGMENTATION PEROXIDATION MOUSE
学科领域	Life Sciences & Biomedicine - Other Topics
DOI	10.1007/s11427-022-2265-6
WOS记录号	WOS:000954699000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74819
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang,Xiaoyu,Chen,Yonghong,Zhang,Longlong,et al. Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis[J]. SCIENCE CHINA-LIFE SCIENCES,2023.
APA	Yang,Xiaoyu.,Chen,Yonghong.,Zhang,Longlong.,He,Jiangbo.,Wu,Qunfu.,...&Niu,Xuemei.(2023).Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis.SCIENCE CHINA-LIFE SCIENCES.
MLA	Yang,Xiaoyu,et al."Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis".SCIENCE CHINA-LIFE SCIENCES (2023).

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