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| Recent Studies on Protective Effects of Walnuts against Neuroinflammation | |
| Tan, Bing; Wang, Yuxi; Zhang, Xudong; Sun, Xiangjun | |
| 2022 | |
| Source Publication | NUTRIENTS
 |
| Volume | 14Issue:20Pages:4360 |
| Abstract | Neuroinflammation plays a significant role in the aging process and the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease. Accordingly, possible therapeutic strategies aimed at anti-inflammatory effects may be beneficial to brain health. Walnut kernels contain large quantities of unsaturated fatty acids, peptides, and phenolic compounds that have anti-inflammatory effects. The long-term intake of walnuts has been found to improve cognitive function and memory in rats and humans. However, the modulatory effect of walnuts on neuroinflammation has received much less attention. This review focuses on the potential influence and main regulating mechanisms of walnuts and their active ingredients on neuroinflammation, including the regulation of microglia activation induced by amyloid beta or lipopolysaccharides, inhibition of peripheral inflammation mediated by macrophages, reduction in oxidative stress by decreasing free radical levels and boosting antioxidant defenses, and control of gut microbes to maintain homeostasis. However, the majority of evidence of the beneficial effects of walnuts or their components on neuroinflammation and neurodegeneration comes from experimental work, whereas evidence from clinical studies on the beneficial effects is scarcer and less conclusive. This review aims to provide new insights into the neuroinflammation-regulating mechanisms and natural active ingredients of walnuts and the development of walnut-based functional foods for the alleviation of neurodegenerative diseases. |
| Keyword | walnuts neuroinflammation neurodegenerative diseases oxidative stress antioxidant activity gut microbes ALPHA-LINOLENIC ACID BETA-AMYLOID PROTEIN NF-KAPPA-B OXIDATIVE STRESS COGNITIVE IMPAIRMENT MEDITERRANEAN DIET INDUCED ACTIVATION BV-2 MICROGLIA ELLAGIC ACID GALLIC ACID |
| DOI | 10.3390/nu14204360 |
| Indexed By | SCI |
| WOS ID | WOS:000875955500001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/74791 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Tan, Bing,Wang, Yuxi,Zhang, Xudong,et al. Recent Studies on Protective Effects of Walnuts against Neuroinflammation[J]. NUTRIENTS,2022,14(20):4360. |
| APA | Tan, Bing,Wang, Yuxi,Zhang, Xudong,&Sun, Xiangjun.(2022).Recent Studies on Protective Effects of Walnuts against Neuroinflammation.NUTRIENTS,14(20),4360. |
| MLA | Tan, Bing,et al."Recent Studies on Protective Effects of Walnuts against Neuroinflammation".NUTRIENTS 14.20(2022):4360. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| ARTN 4360.pdf（999KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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