Recent Studies on Protective Effects of Walnuts against Neuroinflammation

doi:10.3390/nu14204360

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	Recent Studies on Protective Effects of Walnuts against Neuroinflammation
	Tan, Bing; Wang, Yuxi; Zhang, Xudong; Sun, Xiangjun
	2022
发表期刊	NUTRIENTS
卷号	14 期号:20 页码:4360
摘要	Neuroinflammation plays a significant role in the aging process and the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease. Accordingly, possible therapeutic strategies aimed at anti-inflammatory effects may be beneficial to brain health. Walnut kernels contain large quantities of unsaturated fatty acids, peptides, and phenolic compounds that have anti-inflammatory effects. The long-term intake of walnuts has been found to improve cognitive function and memory in rats and humans. However, the modulatory effect of walnuts on neuroinflammation has received much less attention. This review focuses on the potential influence and main regulating mechanisms of walnuts and their active ingredients on neuroinflammation, including the regulation of microglia activation induced by amyloid beta or lipopolysaccharides, inhibition of peripheral inflammation mediated by macrophages, reduction in oxidative stress by decreasing free radical levels and boosting antioxidant defenses, and control of gut microbes to maintain homeostasis. However, the majority of evidence of the beneficial effects of walnuts or their components on neuroinflammation and neurodegeneration comes from experimental work, whereas evidence from clinical studies on the beneficial effects is scarcer and less conclusive. This review aims to provide new insights into the neuroinflammation-regulating mechanisms and natural active ingredients of walnuts and the development of walnut-based functional foods for the alleviation of neurodegenerative diseases.
关键词	walnuts neuroinflammation neurodegenerative diseases oxidative stress antioxidant activity gut microbes ALPHA-LINOLENIC ACID BETA-AMYLOID PROTEIN NF-KAPPA-B OXIDATIVE STRESS COGNITIVE IMPAIRMENT MEDITERRANEAN DIET INDUCED ACTIVATION BV-2 MICROGLIA ELLAGIC ACID GALLIC ACID
DOI	10.3390/nu14204360
收录类别	SCI
WOS记录号	WOS:000875955500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74791
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Tan, Bing,Wang, Yuxi,Zhang, Xudong,et al. Recent Studies on Protective Effects of Walnuts against Neuroinflammation[J]. NUTRIENTS,2022,14(20):4360.
APA	Tan, Bing,Wang, Yuxi,Zhang, Xudong,&Sun, Xiangjun.(2022).Recent Studies on Protective Effects of Walnuts against Neuroinflammation.NUTRIENTS,14(20),4360.
MLA	Tan, Bing,et al."Recent Studies on Protective Effects of Walnuts against Neuroinflammation".NUTRIENTS 14.20(2022):4360.

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