Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats

doi:10.1080/13880209.2021.2021947

KIB OpenIR

	Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats
	Zhao, Yun-Li; Zhang, Xiang-Hua; Guo, Feng; Wei, Ying; Shang, Jian-Hua; Luo, Xiao-Dong
	2022
发表期刊	PHARMACEUTICAL BIOLOGY
卷号	60 期号:1 页码:163-174
摘要	Context Yi Shen An (YSA) is an investigational composite of traditional Chinese medicine (Reference: 2010L000974) for the treatment of renal disease. Objective To investigate the protective effects of YSA against membranous glomerulonephritis (MGN). Materials and methods Male Sprague-Dawley rats were injected with cationic bovine serum albumin (C-BSA) to create a model of MGN. Then, rats were orally treated with YSA at doses of 0.25, 0.5, 1 and 2 g/kg for 35 successive days; prednisone (5 mg/kg) was used as a positive control. At the end of the experimental period, we performed a series of tests, including 24 h urinary protein, and biochemical, immunological, antioxidative, coagulation indices, and histopathological examination. Results YSA-1 g/kg significantly lowered urinary protein from 68.37 to 30.74 mg (p < 0.01). Meantime, total protein (TP) and albumin (ALB) recovered from 66.26 and 20.51 g/L to 76.08 and 35.64 g/L (p < 0.01), respectively. YSA removed the deposition of immunoglobulin G (IgG) and complement 3c (C3c), prevented inter-capillary cell hyperplasia on the glomerular basement membrane (GBM), and reduced electron-dense deposits and fusion of podocytes. In addition, serum IgG and superoxide dismutase were significantly elevated. In contrast, malondialdehyde, total cholesterol, triglyceride, circulating immune complex (CIC), and immunoglobulin M decreased in the YSA-treated group. Moreover, the blood coagulation dysfunction was adjusted. Discussion and conclusions These findings indicate YSA may exert a therapeutic effect against MGN through the inhibition of CIC formation, and the removal of IgG and C3c deposition from the GBM, thus supporting the development of further clinical trials.
关键词	Nephritis circulating immune complex proteinuria podocytes OXIDATIVE STRESS DIABETIC-NEPHROPATHY NEPHROTIC SYNDROME GLOMERULAR INJURY PATHOGENESIS COMPLEMENT INFLAMMATION PROGRESSION NEPHRITIS CELLS
DOI	10.1080/13880209.2021.2021947
收录类别	SCI
WOS记录号	WOS:000740524000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74762
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhao, Yun-Li,Zhang, Xiang-Hua,Guo, Feng,et al. Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats[J]. PHARMACEUTICAL BIOLOGY,2022,60(1):163-174.
APA	Zhao, Yun-Li,Zhang, Xiang-Hua,Guo, Feng,Wei, Ying,Shang, Jian-Hua,&Luo, Xiao-Dong.(2022).Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats.PHARMACEUTICAL BIOLOGY,60(1),163-174.
MLA	Zhao, Yun-Li,et al."Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats".PHARMACEUTICAL BIOLOGY 60.1(2022):163-174.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
10.1080_13880209.202（2887KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载