Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense

doi:10.25135/rnp.260.21.04.2048

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	Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense
	Chen, Xiaoxiao; Hu, Jiaomiao; Wu, Siyu; Zhao, Hongsu; Peng, Daiyin; Wu, Deling; Xu, Fengqing
	2022
发表期刊	RECORDS OF NATURAL PRODUCTS
卷号	16 期号:2 页码:144-149
摘要	Bioassay-guided led to the isolation of five compounds, including a new picrotoxane-type sesquiterpene lactone, aduncin C (1), together with four known ones (2-5) from Dendrobium huoshanense. Their structures were elucidated by means of extensive spectroscopic analysis. Biological evaluation of the isolates against four human cancer cell lines indicated broad-spectrum and cytotoxic activities with IC50 values ranging from 4.08 to 26.75 mu M. Among them, alpha-dihydropicrotoxinin (3) exhibited significant cell proliferation inhibitory activity, especially for HL-60 (IC50 5.81 mu M), MCF- 7 (IC50 6.49 mu M), SW-480 (IC50 6.80 mu M), respectively.
关键词	Dendrobium huoshanense picrotoxane-type sesquiterpene cytotoxicity CHEMICAL-CONSTITUENTS
DOI	10.25135/rnp.260.21.04.2048
收录类别	SCI
WOS记录号	WOS:000690403000004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74717
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen, Xiaoxiao,Hu, Jiaomiao,Wu, Siyu,et al. Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense[J]. RECORDS OF NATURAL PRODUCTS,2022,16(2):144-149.
APA	Chen, Xiaoxiao.,Hu, Jiaomiao.,Wu, Siyu.,Zhao, Hongsu.,Peng, Daiyin.,...&Xu, Fengqing.(2022).Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense.RECORDS OF NATURAL PRODUCTS,16(2),144-149.
MLA	Chen, Xiaoxiao,et al."Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense".RECORDS OF NATURAL PRODUCTS 16.2(2022):144-149.

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