Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives

doi:10.1134/S1070428022120156

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	Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives
	Hu, X. X.; Huang, Z. F.; Lu, G. S.; Huang, J. Y.; Li, X. N.; Tan, X.; Feng, D.
	2022
发表期刊	RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
卷号	58 期号:12 页码:1861-1867
摘要	Two acetyl chroman derivative, 1-(5,7-dihydroxy-2,2-dimethylchroman-8-yl)ethan-1-one (1) and 1-(5,7-dihydroxy-2,2-dimethylchroman-6-yl)ethan-1-one (2) were synthesized as intermediate products in the preparation of flavonoids. Their structures were characterized by NMR and IR and confirmed by high-resolution mass spectra and single crystal X-ray analysis. The inhibitory effects of the synthesized compounds on the growth of A549, HepG2, SW480, and MCF-7 cancer cell lines were evaluated by the CCK8 methods. Compound 1 showed cytotoxicity against HepG2, SW480, and MCF-7 cell lines with IC50 values of 12.85, 23.94, and 28.72 mu M, respectively, and compound 2 showed cytotoxicity against HepG2 and MCF-7 cell lines with IC50 values of 24.78 and 23.87 mu M, respectively.
关键词	acetyl chroman derivative X-ray analysis crystal structures cytotoxicity
DOI	10.1134/S1070428022120156
收录类别	SCI
WOS记录号	WOS:000933777000015
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74671
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Hu, X. X.,Huang, Z. F.,Lu, G. S.,et al. Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives[J]. RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,2022,58(12):1861-1867.
APA	Hu, X. X..,Huang, Z. F..,Lu, G. S..,Huang, J. Y..,Li, X. N..,...&Feng, D..(2022).Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives.RUSSIAN JOURNAL OF ORGANIC CHEMISTRY,58(12),1861-1867.
MLA	Hu, X. X.,et al."Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives".RUSSIAN JOURNAL OF ORGANIC CHEMISTRY 58.12(2022):1861-1867.

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