植物源抗双生病毒活性化合物的筛选和作用机制研究

	植物源抗双生病毒活性化合物的筛选和作用机制研究; THE SCREENING AND MECHANISM OF PLANT DERIVED ANTIGEMINIVIRUSES COMPOUNDS
	李玉林
导师	郝小江
摘要	Begomoviruses (Family Geminiviridae), the largest genus of plant viruses with single stranded circular DNA, could infect large range of plants including grasses, solanaceae, Malvaceae, Cruciferae, legumes and other crops. Begomoviruses are insect vector whitefly (Bemisia tabaci ) transmitted plant viruses, causing devastating damage to crop production around the world. So far there is no efficient optionally available antiviral drugs, mainly due to the narrow resistance spectrum, and fast viral genome variation of geminivirus, the mutualism between geminivirus and their insects. In the field crop protection, it mainly rely on the use of chemical pesticides to kill whiteflies for prevention and control. However, problems such as insecticide resistance, environment pollution and food safety appeal for efficient and environmental safe drugs against whitefly transmitted geminivirus. The study is aimed to establish a high-throughput platform for screening natural compounds against Bemisia tabaci transmitted geminivirus, from traditional Chinese medicine, and further analyze the mechanism of action of antiviral compounds. A broad spectrum of anti-arboviruses natural products were obtained in our study, and the preliminary resistance mechanism of GSX3 as a plant immune agonist activation MKK2 were also illustrated. These results provided a new prodrug to establish effective prevention and control method for geminvirus, which would further resolve the plant broad-spectrum resistance to laid a solid foundation, new molecular targets for the broad spectrum of arboviruses by gene editing or molecular breeding.
	2021-05
文献类型	学位论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74634
专题	昆明植物所硕博研究生毕业学位论文
推荐引用方式 GB/T 7714	李玉林. 植物源抗双生病毒活性化合物的筛选和作用机制研究, THE SCREENING AND MECHANISM OF PLANT DERIVED ANTIGEMINIVIRUSES COMPOUNDS[D],2021.

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